{
  "url": "https://dantelabs.com/traits/onycholysis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "onycholysis",
    "id": "HP:0001806",
    "name": "Detachment of nail",
    "label": "Onycholysis",
    "definition": "Detachment of the nail from the nail bed.",
    "synonyms": [
      "Oncholysis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nail-attachment",
        "name": "Abnormal nail attachment",
        "url": "https://dantelabs.com/traits/abnormal-nail-attachment"
      }
    ],
    "narrower": [
      {
        "slug": "onychomadesis",
        "name": "Onychomadesis",
        "genes": 2,
        "url": "https://dantelabs.com/traits/onychomadesis"
      },
      {
        "slug": "recurrent-loss-of-toenails-and-fingernails",
        "name": "Recurrent loss of toenails and fingernails",
        "genes": 2,
        "url": "https://dantelabs.com/traits/recurrent-loss-of-toenails-and-fingernails"
      },
      {
        "slug": "onycholysis-of-fingernails",
        "name": "Detachment of fingernails",
        "genes": 1,
        "url": "https://dantelabs.com/traits/onycholysis-of-fingernails"
      }
    ],
    "genes": [
      {
        "slug": "dsg1",
        "symbol": "DSG1",
        "hgnc": "HGNC:3048",
        "name": "desmoglein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsg1"
      },
      {
        "slug": "fzd6",
        "symbol": "FZD6",
        "hgnc": "HGNC:4044",
        "name": "frizzled class receptor 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fzd6"
      },
      {
        "slug": "itga3",
        "symbol": "ITGA3",
        "hgnc": "HGNC:6139",
        "name": "integrin subunit alpha 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga3"
      },
      {
        "slug": "krt74",
        "symbol": "KRT74",
        "hgnc": "HGNC:28929",
        "name": "keratin 74",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt74"
      },
      {
        "slug": "atr",
        "symbol": "ATR",
        "hgnc": "HGNC:882",
        "name": "ATR checkpoint kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atr"
      },
      {
        "slug": "cast",
        "symbol": "CAST",
        "hgnc": "HGNC:1515",
        "name": "calpastatin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cast"
      },
      {
        "slug": "cdsn",
        "symbol": "CDSN",
        "hgnc": "HGNC:1802",
        "name": "corneodesmosin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdsn"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "ppp1r13l",
        "symbol": "PPP1R13L",
        "hgnc": "HGNC:18838",
        "name": "protein phosphatase 1 regulatory subunit 13 like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1r13l"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "hgnc": "HGNC:4288",
        "name": "gap junction protein beta 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb6"
      },
      {
        "slug": "hla-c",
        "symbol": "HLA-C",
        "hgnc": "HGNC:4933",
        "name": "major histocompatibility complex, class I, C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-c"
      },
      {
        "slug": "ifih1",
        "symbol": "IFIH1",
        "hgnc": "HGNC:18873",
        "name": "interferon induced with helicase C domain 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifih1"
      },
      {
        "slug": "jup",
        "symbol": "JUP",
        "hgnc": "HGNC:6207",
        "name": "junction plakoglobin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jup"
      },
      {
        "slug": "krt85",
        "symbol": "KRT85",
        "hgnc": "HGNC:6462",
        "name": "keratin 85",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt85"
      },
      {
        "slug": "urod",
        "symbol": "UROD",
        "hgnc": "HGNC:12591",
        "name": "uroporphyrinogen decarboxylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/urod"
      },
      {
        "slug": "wnt10a",
        "symbol": "WNT10A",
        "hgnc": "HGNC:13829",
        "name": "Wnt family member 10A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10a"
      }
    ]
  }
}