{
  "url": "https://dantelabs.com/traits/microlissencephaly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "microlissencephaly",
    "id": "HP:0045028",
    "name": "Microlissencephaly",
    "definition": "Severe microcephaly and lissencephaly with granular surfaces with immature cortical plate, reduced in thickness, with focal polymicrogyria and immature small neurons with rare processes, intermingled with a considerable number of glial elements.",
    "synonyms": [
      "Lissencephaly type III",
      "Type 3 lissencephaly",
      "Type III lissencephaly"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "lissencephaly",
        "name": "Fewer or absent grooves in brain",
        "url": "https://dantelabs.com/traits/lissencephaly"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "katnb1",
        "symbol": "KATNB1",
        "hgnc": "HGNC:6217",
        "name": "katanin regulatory subunit B1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/katnb1"
      },
      {
        "slug": "nde1",
        "symbol": "NDE1",
        "hgnc": "HGNC:17619",
        "name": "nudE neurodevelopment protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nde1"
      },
      {
        "slug": "reln",
        "symbol": "RELN",
        "hgnc": "HGNC:9957",
        "name": "reelin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/reln"
      },
      {
        "slug": "kif14",
        "symbol": "KIF14",
        "hgnc": "HGNC:19181",
        "name": "kinesin family member 14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif14"
      },
      {
        "slug": "rnu4atac",
        "symbol": "RNU4ATAC",
        "hgnc": "HGNC:34016",
        "name": "RNA, U4atac small nuclear",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4atac"
      },
      {
        "slug": "cit",
        "symbol": "CIT",
        "hgnc": "HGNC:1985",
        "name": "citron rho-interacting serine/threonine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cit"
      }
    ]
  }
}