{
  "url": "https://dantelabs.com/traits/low-self-esteem",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "low-self-esteem",
    "id": "HP:0031469",
    "name": "Low self-esteem",
    "definition": "Persistent, excessively negative, and critical thoughts of one's personal abilities, attributes, or any feature related to the self and self-attitude. The affected individual believes they are a lesser being compared to others in their social peer group.",
    "synonyms": [
      "Worthlessness"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "cognitive-distortion",
        "name": "Cognitive distortion",
        "url": "https://dantelabs.com/traits/cognitive-distortion"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fmo3",
        "symbol": "FMO3",
        "hgnc": "HGNC:3771",
        "name": "flavin containing dimethylaniline monoxygenase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fmo3"
      },
      {
        "slug": "cacna1h",
        "symbol": "CACNA1H",
        "hgnc": "HGNC:1395",
        "name": "calcium voltage-gated channel subunit alpha1 H",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1h"
      },
      {
        "slug": "gabra1",
        "symbol": "GABRA1",
        "hgnc": "HGNC:4075",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra1"
      },
      {
        "slug": "gabrb3",
        "symbol": "GABRB3",
        "hgnc": "HGNC:4083",
        "name": "gamma-aminobutyric acid type A receptor subunit beta3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabrb3"
      },
      {
        "slug": "gabrg2",
        "symbol": "GABRG2",
        "hgnc": "HGNC:4087",
        "name": "gamma-aminobutyric acid type A receptor subunit gamma2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabrg2"
      },
      {
        "slug": "irf6",
        "symbol": "IRF6",
        "hgnc": "HGNC:6121",
        "name": "interferon regulatory factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf6"
      },
      {
        "slug": "jrk",
        "symbol": "JRK",
        "hgnc": "HGNC:6199",
        "name": "Jrk helix-turn-helix protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jrk"
      },
      {
        "slug": "msx1",
        "symbol": "MSX1",
        "hgnc": "HGNC:7391",
        "name": "msh homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx1"
      },
      {
        "slug": "nectin1",
        "symbol": "NECTIN1",
        "hgnc": "HGNC:9706",
        "name": "nectin cell adhesion molecule 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nectin1"
      },
      {
        "slug": "taf11",
        "symbol": "TAF11",
        "hgnc": "HGNC:11544",
        "name": "TATA-box binding protein associated factor 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf11"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      }
    ]
  }
}