{
  "url": "https://dantelabs.com/traits/lipoma",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "lipoma",
    "id": "HP:0012032",
    "name": "Fatty lump",
    "label": "Lipoma",
    "definition": "Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous.",
    "synonyms": [
      "Noncancerous fatty lump"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "lipomatous-tumor",
        "name": "Lipomatous tumor",
        "url": "https://dantelabs.com/traits/lipomatous-tumor"
      }
    ],
    "narrower": [
      {
        "slug": "frontal-cutaneous-lipoma",
        "name": "Frontal cutaneous lipoma",
        "genes": 1,
        "url": "https://dantelabs.com/traits/frontal-cutaneous-lipoma"
      },
      {
        "slug": "lipoma-of-the-tongue",
        "name": "Lipoma of the tongue",
        "genes": 1,
        "url": "https://dantelabs.com/traits/lipoma-of-the-tongue"
      },
      {
        "slug": "spinal-lipoma",
        "name": "Spinal lipoma",
        "genes": 0,
        "url": "https://dantelabs.com/traits/spinal-lipoma"
      }
    ],
    "genes": [
      {
        "slug": "mad1l1",
        "symbol": "MAD1L1",
        "hgnc": "HGNC:6762",
        "name": "mitotic arrest deficient 1 like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mad1l1"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "ppp2r5c",
        "symbol": "PPP2R5C",
        "hgnc": "HGNC:9311",
        "name": "protein phosphatase 2 regulatory subunit B'gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2r5c"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "msto1",
        "symbol": "MSTO1",
        "hgnc": "HGNC:29678",
        "name": "misato mitochondrial distribution and morphology regulator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msto1"
      },
      {
        "slug": "coq6",
        "symbol": "COQ6",
        "hgnc": "HGNC:20233",
        "name": "coenzyme Q6, monooxygenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq6"
      },
      {
        "slug": "lztr1",
        "symbol": "LZTR1",
        "hgnc": "HGNC:6742",
        "name": "leucine zipper like post translational regulator 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lztr1"
      },
      {
        "slug": "nf2",
        "symbol": "NF2",
        "hgnc": "HGNC:7773",
        "name": "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf2"
      },
      {
        "slug": "rpl10",
        "symbol": "RPL10",
        "hgnc": "HGNC:10298",
        "name": "ribosomal protein L10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl10"
      },
      {
        "slug": "smarcb1",
        "symbol": "SMARCB1",
        "hgnc": "HGNC:11103",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcb1"
      },
      {
        "slug": "taf1",
        "symbol": "TAF1",
        "hgnc": "HGNC:11535",
        "name": "TATA-box binding protein associated factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf1"
      },
      {
        "slug": "apc",
        "symbol": "APC",
        "hgnc": "HGNC:583",
        "name": "APC regulator of Wnt signaling pathway",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc"
      },
      {
        "slug": "cdc73",
        "symbol": "CDC73",
        "hgnc": "HGNC:16783",
        "name": "cell division cycle 73",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cdc73"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "fuz",
        "symbol": "FUZ",
        "hgnc": "HGNC:26219",
        "name": "fuzzy planar cell polarity protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fuz"
      },
      {
        "slug": "tbxt",
        "symbol": "TBXT",
        "hgnc": "HGNC:11515",
        "name": "T-box transcription factor T",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbxt"
      },
      {
        "slug": "vangl1",
        "symbol": "VANGL1",
        "hgnc": "HGNC:15512",
        "name": "VANGL planar cell polarity protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vangl1"
      },
      {
        "slug": "vangl2",
        "symbol": "VANGL2",
        "hgnc": "HGNC:15511",
        "name": "VANGL planar cell polarity protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vangl2"
      }
    ]
  }
}