{
  "url": "https://dantelabs.com/traits/hyperpigmented-hypopigmented-macules",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hyperpigmented-hypopigmented-macules",
    "id": "HP:0007441",
    "name": "Hyperpigmented/hypopigmented macules",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "macule",
        "name": "Flat, discolored area of skin",
        "url": "https://dantelabs.com/traits/macule"
      },
      {
        "slug": "mixed-hypo-and-hyperpigmentation-of-the-skin",
        "name": "Mixed hypo- and hyperpigmentation of the skin",
        "url": "https://dantelabs.com/traits/mixed-hypo-and-hyperpigmentation-of-the-skin"
      }
    ],
    "narrower": [
      {
        "slug": "discrete-2-to-5-mm-hyper-and-hypopigmented-macules",
        "name": "Discrete 2 to 5-mm hyper- and hypopigmented macules",
        "genes": 1,
        "url": "https://dantelabs.com/traits/discrete-2-to-5-mm-hyper-and-hypopigmented-macules"
      }
    ],
    "genes": [
      {
        "slug": "dpp9",
        "symbol": "DPP9",
        "hgnc": "HGNC:18648",
        "name": "dipeptidyl peptidase 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpp9"
      },
      {
        "slug": "pign",
        "symbol": "PIGN",
        "hgnc": "HGNC:8967",
        "name": "phosphatidylinositol glycan anchor biosynthesis class N",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pign"
      },
      {
        "slug": "adar",
        "symbol": "ADAR",
        "hgnc": "HGNC:225",
        "name": "adenosine deaminase RNA specific",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adar"
      },
      {
        "slug": "sash1",
        "symbol": "SASH1",
        "hgnc": "HGNC:19182",
        "name": "SAM and SH3 domain containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sash1"
      }
    ]
  }
}