{
  "url": "https://dantelabs.com/traits/hyperparakeratosis",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "hyperparakeratosis",
    "id": "HP:0040009",
    "name": "Hyperparakeratosis",
    "definition": "Histological term to illustrate the combined presence of parakeratosis and hyperkeratosis. Abnormal keratinization of the epidermal stratum corneum (horny layer) with increased keratin formation and preservation of the nuclei in the superficial cells.",
    "synonyms": [
      "Parahyperkeratosis",
      "Parakeratotic hyperkeratosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "hyperkeratosis",
        "name": "Hyperkeratosis",
        "url": "https://dantelabs.com/traits/hyperkeratosis"
      },
      {
        "slug": "parakeratosis",
        "name": "Parakeratosis",
        "url": "https://dantelabs.com/traits/parakeratosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "krt10",
        "symbol": "KRT10",
        "hgnc": "HGNC:6413",
        "name": "keratin 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt10"
      },
      {
        "slug": "trpv3",
        "symbol": "TRPV3",
        "hgnc": "HGNC:18084",
        "name": "transient receptor potential cation channel subfamily V member 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv3"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "krt13",
        "symbol": "KRT13",
        "hgnc": "HGNC:6415",
        "name": "keratin 13",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt13"
      }
    ]
  }
}