{
  "url": "https://dantelabs.com/traits/hyperglutaminemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hyperglutaminemia",
    "id": "HP:0003217",
    "name": "High plasma glutamine",
    "label": "Hyperglutaminemia",
    "definition": "The concentration of glutamine in the blood circulation is above the upper limit of normal.",
    "synonyms": [
      "Elevated glutamine concentration",
      "Elevated glutamine level",
      "Elevated glutamine level in blood",
      "Increased glutamine concentration",
      "Increased glutamine level",
      "Increased glutamine level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-glutamine-concentration",
        "name": "Abnormal circulating glutamine concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-glutamine-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ass1",
        "symbol": "ASS1",
        "hgnc": "HGNC:758",
        "name": "argininosuccinate synthase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ass1"
      },
      {
        "slug": "gls",
        "symbol": "GLS",
        "hgnc": "HGNC:4331",
        "name": "glutaminase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gls"
      },
      {
        "slug": "lipt1",
        "symbol": "LIPT1",
        "hgnc": "HGNC:29569",
        "name": "lipoyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipt1"
      },
      {
        "slug": "nags",
        "symbol": "NAGS",
        "hgnc": "HGNC:17996",
        "name": "N-acetylglutamate synthase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nags"
      },
      {
        "slug": "asl",
        "symbol": "ASL",
        "hgnc": "HGNC:746",
        "name": "argininosuccinate lyase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/asl"
      },
      {
        "slug": "ca5a",
        "symbol": "CA5A",
        "hgnc": "HGNC:1377",
        "name": "carbonic anhydrase 5A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca5a"
      },
      {
        "slug": "cox16",
        "symbol": "COX16",
        "hgnc": "HGNC:20213",
        "name": "cytochrome c oxidase assembly factor COX16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox16"
      },
      {
        "slug": "pck1",
        "symbol": "PCK1",
        "hgnc": "HGNC:8724",
        "name": "phosphoenolpyruvate carboxykinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pck1"
      },
      {
        "slug": "pck2",
        "symbol": "PCK2",
        "hgnc": "HGNC:8725",
        "name": "phosphoenolpyruvate carboxykinase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pck2"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "otc",
        "symbol": "OTC",
        "hgnc": "HGNC:8512",
        "name": "ornithine transcarbamylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otc"
      }
    ]
  }
}