{
  "url": "https://dantelabs.com/traits/glossoptosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "glossoptosis",
    "id": "HP:0000162",
    "name": "Retraction of the tongue",
    "label": "Glossoptosis",
    "definition": "Posterior displacement of the tongue into the pharynx, i.e., a tongue that is mislocalised posteriorly.",
    "synonyms": [
      "Lingual retraction"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-tongue-morphology",
        "name": "Abnormal tongue morphology",
        "url": "https://dantelabs.com/traits/abnormal-tongue-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "amotl1",
        "symbol": "AMOTL1",
        "hgnc": "HGNC:17811",
        "name": "angiomotin like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amotl1"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "med16",
        "symbol": "MED16",
        "hgnc": "HGNC:17556",
        "name": "mediator complex subunit 16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med16"
      },
      {
        "slug": "nfasc",
        "symbol": "NFASC",
        "hgnc": "HGNC:29866",
        "name": "neurofascin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfasc"
      },
      {
        "slug": "btk",
        "symbol": "BTK",
        "hgnc": "HGNC:1133",
        "name": "Bruton tyrosine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btk"
      },
      {
        "slug": "sox9",
        "symbol": "SOX9",
        "hgnc": "HGNC:11204",
        "name": "SRY-box transcription factor 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox9"
      },
      {
        "slug": "tgds",
        "symbol": "TGDS",
        "hgnc": "HGNC:20324",
        "name": "TDP-glucose 4,6-dehydratase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tgds"
      },
      {
        "slug": "chd6",
        "symbol": "CHD6",
        "hgnc": "HGNC:19057",
        "name": "chromodomain helicase DNA binding protein 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd6"
      },
      {
        "slug": "cog1",
        "symbol": "COG1",
        "hgnc": "HGNC:6545",
        "name": "component of oligomeric golgi complex 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog1"
      },
      {
        "slug": "col11a1",
        "symbol": "COL11A1",
        "hgnc": "HGNC:2186",
        "name": "collagen type XI alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col11a1"
      },
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "hgnc": "HGNC:2187",
        "name": "collagen type XI alpha 2 chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col11a2"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "edn1",
        "symbol": "EDN1",
        "hgnc": "HGNC:3176",
        "name": "endothelin 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/edn1"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "gnai3",
        "symbol": "GNAI3",
        "hgnc": "HGNC:4387",
        "name": "G protein subunit alpha i3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gnai3"
      },
      {
        "slug": "hdac9",
        "symbol": "HDAC9",
        "hgnc": "HGNC:14065",
        "name": "histone deacetylase 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac9"
      },
      {
        "slug": "mymk",
        "symbol": "MYMK",
        "hgnc": "HGNC:33778",
        "name": "myomaker, myoblast fusion factor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mymk"
      },
      {
        "slug": "mymx",
        "symbol": "MYMX",
        "hgnc": "HGNC:52391",
        "name": "myomixer, myoblast fusion factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mymx"
      },
      {
        "slug": "plcb4",
        "symbol": "PLCB4",
        "hgnc": "HGNC:9059",
        "name": "phospholipase C beta 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/plcb4"
      },
      {
        "slug": "rbm10",
        "symbol": "RBM10",
        "hgnc": "HGNC:9896",
        "name": "RNA binding motif protein 10",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rbm10"
      },
      {
        "slug": "slc35b2",
        "symbol": "SLC35B2",
        "hgnc": "HGNC:16872",
        "name": "solute carrier family 35 member B2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35b2"
      },
      {
        "slug": "snrpb",
        "symbol": "SNRPB",
        "hgnc": "HGNC:11153",
        "name": "small nuclear ribonucleoprotein polypeptides B and B1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/snrpb"
      },
      {
        "slug": "aff4",
        "symbol": "AFF4",
        "hgnc": "HGNC:17869",
        "name": "ALF transcription elongation factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aff4"
      },
      {
        "slug": "ednra",
        "symbol": "EDNRA",
        "hgnc": "HGNC:3179",
        "name": "endothelin receptor type A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ednra"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "polr1b",
        "symbol": "POLR1B",
        "hgnc": "HGNC:20454",
        "name": "RNA polymerase I subunit B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1b"
      },
      {
        "slug": "polr1c",
        "symbol": "POLR1C",
        "hgnc": "HGNC:20194",
        "name": "RNA polymerase I and III subunit C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1c"
      },
      {
        "slug": "polr1d",
        "symbol": "POLR1D",
        "hgnc": "HGNC:20422",
        "name": "RNA polymerase I and III subunit D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1d"
      },
      {
        "slug": "rpl17",
        "symbol": "RPL17",
        "hgnc": "HGNC:10307",
        "name": "ribosomal protein L17",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl17"
      },
      {
        "slug": "rspo2",
        "symbol": "RSPO2",
        "hgnc": "HGNC:28583",
        "name": "R-spondin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rspo2"
      },
      {
        "slug": "runx2",
        "symbol": "RUNX2",
        "hgnc": "HGNC:10472",
        "name": "RUNX family transcription factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx2"
      },
      {
        "slug": "tcof1",
        "symbol": "TCOF1",
        "hgnc": "HGNC:11654",
        "name": "treacle ribosome biogenesis factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcof1"
      },
      {
        "slug": "vac14",
        "symbol": "VAC14",
        "hgnc": "HGNC:25507",
        "name": "VAC14 component of PIKFYVE complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vac14"
      },
      {
        "slug": "nfix",
        "symbol": "NFIX",
        "hgnc": "HGNC:7788",
        "name": "nuclear factor I X",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfix"
      },
      {
        "slug": "pex16",
        "symbol": "PEX16",
        "hgnc": "HGNC:8857",
        "name": "peroxisomal biogenesis factor 16",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex16"
      }
    ]
  }
}