{
  "url": "https://dantelabs.com/traits/giant-platelets",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "giant-platelets",
    "id": "HP:0001902",
    "name": "Giant platelets",
    "definition": "Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers. The term giant platelet is used when the platelet is larger than the size of the average red cell in the field. (Description adapted from College of American Pathologists, Hematology Manual, 1998).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "increased-mean-platelet-volume",
        "name": "Large platelets",
        "url": "https://dantelabs.com/traits/increased-mean-platelet-volume"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "abcg8",
        "symbol": "ABCG8",
        "hgnc": "HGNC:13887",
        "name": "ATP binding cassette subfamily G member 8",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcg8"
      },
      {
        "slug": "gale",
        "symbol": "GALE",
        "hgnc": "HGNC:4116",
        "name": "UDP-galactose-4-epimerase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gale"
      },
      {
        "slug": "itga2b",
        "symbol": "ITGA2B",
        "hgnc": "HGNC:6138",
        "name": "integrin subunit alpha 2b",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga2b"
      },
      {
        "slug": "myh9",
        "symbol": "MYH9",
        "hgnc": "HGNC:7579",
        "name": "myosin heavy chain 9",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/myh9"
      },
      {
        "slug": "gp1ba",
        "symbol": "GP1BA",
        "hgnc": "HGNC:4439",
        "name": "glycoprotein Ib platelet subunit alpha",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp1ba"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "gp9",
        "symbol": "GP9",
        "hgnc": "HGNC:4444",
        "name": "glycoprotein IX platelet",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp9"
      },
      {
        "slug": "slc35a1",
        "symbol": "SLC35A1",
        "hgnc": "HGNC:11021",
        "name": "solute carrier family 35 member A1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35a1"
      },
      {
        "slug": "abcg5",
        "symbol": "ABCG5",
        "hgnc": "HGNC:13886",
        "name": "ATP binding cassette subfamily G member 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcg5"
      },
      {
        "slug": "cog1",
        "symbol": "COG1",
        "hgnc": "HGNC:6545",
        "name": "component of oligomeric golgi complex 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog1"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "cd36",
        "symbol": "CD36",
        "hgnc": "HGNC:1663",
        "name": "CD36 molecule (CD36 blood group)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd36"
      }
    ]
  }
}