{
  "url": "https://dantelabs.com/traits/fibroma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "fibroma",
    "id": "HP:0010614",
    "name": "Fibroma",
    "definition": "Benign tumors that are composed of fibrous or connective tissue. They can grow in all organs, arising from mesenchyme tissue. The term \"fibroblastic\" or \"fibromatous\" is used to describe tumors of the fibrous connective tissue. When the term fibroma is used without modifier, it is usually considered benign, with the term fibrosarcoma reserved for malignant tumors.",
    "synonyms": [],
    "systems": [
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "fibrous-tissue-neoplasm",
        "name": "Fibrous tissue neoplasm",
        "url": "https://dantelabs.com/traits/fibrous-tissue-neoplasm"
      },
      {
        "slug": "soft-tissue-sarcoma",
        "name": "Soft tissue sarcoma",
        "url": "https://dantelabs.com/traits/soft-tissue-sarcoma"
      }
    ],
    "narrower": [
      {
        "slug": "gingival-fibromatosis",
        "name": "Gingival fibromatosis",
        "genes": 20,
        "url": "https://dantelabs.com/traits/gingival-fibromatosis"
      },
      {
        "slug": "neurofibroma",
        "name": "Neurofibroma",
        "genes": 18,
        "url": "https://dantelabs.com/traits/neurofibroma"
      },
      {
        "slug": "angiofibromas",
        "name": "Angiofibromas",
        "genes": 10,
        "url": "https://dantelabs.com/traits/angiofibromas"
      },
      {
        "slug": "fibroadenoma-of-the-breast",
        "name": "Fibroadenoma of the breast",
        "genes": 8,
        "url": "https://dantelabs.com/traits/fibroadenoma-of-the-breast"
      },
      {
        "slug": "cardiac-fibroma",
        "name": "Cardiac fibroma",
        "genes": 3,
        "url": "https://dantelabs.com/traits/cardiac-fibroma"
      },
      {
        "slug": "ovarian-fibroma",
        "name": "Ovarian fibroma",
        "genes": 3,
        "url": "https://dantelabs.com/traits/ovarian-fibroma"
      },
      {
        "slug": "subungual-fibromas",
        "name": "Subungual fibromas",
        "genes": 3,
        "url": "https://dantelabs.com/traits/subungual-fibromas"
      },
      {
        "slug": "ungual-fibroma",
        "name": "Ungual fibroma",
        "genes": 3,
        "url": "https://dantelabs.com/traits/ungual-fibroma"
      },
      {
        "slug": "ossifying-fibroma",
        "name": "Ossifying fibroma",
        "genes": 1,
        "url": "https://dantelabs.com/traits/ossifying-fibroma"
      }
    ],
    "genes": [
      {
        "slug": "il6st",
        "symbol": "IL6ST",
        "hgnc": "HGNC:6021",
        "name": "interleukin 6 cytokine family signal transducer",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il6st"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "apc",
        "symbol": "APC",
        "hgnc": "HGNC:583",
        "name": "APC regulator of Wnt signaling pathway",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/apc"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "cdc73",
        "symbol": "CDC73",
        "hgnc": "HGNC:16783",
        "name": "cell division cycle 73",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cdc73"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "col4a5",
        "symbol": "COL4A5",
        "hgnc": "HGNC:2207",
        "name": "collagen type IV alpha 5 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a5"
      },
      {
        "slug": "col4a6",
        "symbol": "COL4A6",
        "hgnc": "HGNC:2208",
        "name": "collagen type IV alpha 6 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a6"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      }
    ]
  }
}