{
  "url": "https://dantelabs.com/traits/calcific-stippling",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "calcific-stippling",
    "id": "HP:0002832",
    "name": "Calcific stippling",
    "definition": "An abnormal punctate (speckled, dot-like) pattern of calcifications in soft tissues within or surrounding bones (as observed on radiographs).",
    "synonyms": [
      "Discrete calcific stippling"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "ectopic-calcification",
        "name": "Ectopic calcification",
        "url": "https://dantelabs.com/traits/ectopic-calcification"
      }
    ],
    "narrower": [
      {
        "slug": "stippled-chondral-calcification",
        "name": "Stippled chondral calcification",
        "genes": 2,
        "url": "https://dantelabs.com/traits/stippled-chondral-calcification"
      }
    ],
    "genes": [
      {
        "slug": "hsd17b4",
        "symbol": "HSD17B4",
        "hgnc": "HGNC:5213",
        "name": "hydroxysteroid 17-beta dehydrogenase 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd17b4"
      },
      {
        "slug": "ebp",
        "symbol": "EBP",
        "hgnc": "HGNC:3133",
        "name": "EBP cholestenol delta-isomerase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebp"
      },
      {
        "slug": "gnpat",
        "symbol": "GNPAT",
        "hgnc": "HGNC:4416",
        "name": "glyceronephosphate O-acyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnpat"
      }
    ]
  }
}