{
  "url": "https://dantelabs.com/traits/axonal-loss",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "axonal-loss",
    "id": "HP:0003447",
    "name": "Axonal loss",
    "definition": "A reduction in the number of axons in the peripheral nervous system.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "peripheral-axonal-degeneration",
        "name": "Peripheral axonal degeneration",
        "url": "https://dantelabs.com/traits/peripheral-axonal-degeneration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "inf2",
        "symbol": "INF2",
        "hgnc": "HGNC:23791",
        "name": "inverted formin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inf2"
      },
      {
        "slug": "pmp22",
        "symbol": "PMP22",
        "hgnc": "HGNC:9118",
        "name": "peripheral myelin protein 22",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmp22"
      },
      {
        "slug": "rfc1",
        "symbol": "RFC1",
        "hgnc": "HGNC:9969",
        "name": "replication factor C subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfc1"
      },
      {
        "slug": "slc12a6",
        "symbol": "SLC12A6",
        "hgnc": "HGNC:10914",
        "name": "solute carrier family 12 member 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a6"
      },
      {
        "slug": "gdap1",
        "symbol": "GDAP1",
        "hgnc": "HGNC:15968",
        "name": "ganglioside induced differentiation associated protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdap1"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "gjb1",
        "symbol": "GJB1",
        "hgnc": "HGNC:4283",
        "name": "gap junction protein beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb1"
      },
      {
        "slug": "ngly1",
        "symbol": "NGLY1",
        "hgnc": "HGNC:17646",
        "name": "N-glycanase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngly1"
      },
      {
        "slug": "adprs",
        "symbol": "ADPRS",
        "hgnc": "HGNC:21304",
        "name": "ADP-ribosylserine hydrolase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adprs"
      },
      {
        "slug": "ascc1",
        "symbol": "ASCC1",
        "hgnc": "HGNC:24268",
        "name": "activating signal cointegrator 1 complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ascc1"
      },
      {
        "slug": "bag3",
        "symbol": "BAG3",
        "hgnc": "HGNC:939",
        "name": "BAG cochaperone 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bag3"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "mocs1",
        "symbol": "MOCS1",
        "hgnc": "HGNC:7190",
        "name": "molybdenum cofactor synthesis 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mocs1"
      },
      {
        "slug": "mocs2",
        "symbol": "MOCS2",
        "hgnc": "HGNC:7193",
        "name": "molybdenum cofactor synthesis 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mocs2"
      },
      {
        "slug": "ndrg1",
        "symbol": "NDRG1",
        "hgnc": "HGNC:7679",
        "name": "N-myc downstream regulated 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndrg1"
      },
      {
        "slug": "surf1",
        "symbol": "SURF1",
        "hgnc": "HGNC:11474",
        "name": "SURF1 cytochrome c oxidase assembly factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/surf1"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "trip4",
        "symbol": "TRIP4",
        "hgnc": "HGNC:12310",
        "name": "thyroid hormone receptor interactor 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trip4"
      },
      {
        "slug": "tyrobp",
        "symbol": "TYROBP",
        "hgnc": "HGNC:12449",
        "name": "transmembrane immune signaling adaptor TYROBP",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyrobp"
      },
      {
        "slug": "ubqln2",
        "symbol": "UBQLN2",
        "hgnc": "HGNC:12509",
        "name": "ubiquilin 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubqln2"
      },
      {
        "slug": "ubtf",
        "symbol": "UBTF",
        "hgnc": "HGNC:12511",
        "name": "upstream binding transcription factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubtf"
      }
    ]
  }
}