{
  "url": "https://dantelabs.com/traits/abnormal-memory-b-cell-proportion",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-memory-b-cell-proportion",
    "id": "HP:0030373",
    "name": "Abnormal memory B cell proportion",
    "definition": "A deviation of the normal proportion of memory B cells in circulation relative to total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).",
    "synonyms": [
      "Abnormal proportion of memory B cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-b-cell-subset-distribution",
        "name": "Abnormal B cell subset distribution",
        "url": "https://dantelabs.com/traits/abnormal-b-cell-subset-distribution"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-memory-b-cell-proportion",
        "name": "Decreased memory B cell proportion",
        "genes": 13,
        "url": "https://dantelabs.com/traits/decreased-memory-b-cell-proportion"
      },
      {
        "slug": "abnormal-class-switched-memory-b-cell-proportion",
        "name": "Abnormal class-switched memory B cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-class-switched-memory-b-cell-proportion"
      },
      {
        "slug": "abnormal-marginal-zone-b-cell-proportion",
        "name": "Abnormal marginal zone B cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-marginal-zone-b-cell-proportion"
      },
      {
        "slug": "abnormal-unswitched-memory-b-cell-proportion",
        "name": "Abnormal unswitched memory B cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-unswitched-memory-b-cell-proportion"
      }
    ],
    "genes": []
  }
}