{
  "url": "https://dantelabs.com/traits/abnormal-dense-granules",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-dense-granules",
    "id": "HP:0012484",
    "name": "Abnormal dense granules",
    "definition": "Defective structure, size or content of dense granules, platelet organelles that contain granules proaggregatory factors such as adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium, histamine and serotonin.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-platelet-granules",
        "name": "Abnormal platelet granules",
        "url": "https://dantelabs.com/traits/abnormal-platelet-granules"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-dense-granule-content",
        "name": "Abnormal dense granule content",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-dense-granule-content"
      },
      {
        "slug": "abnormal-number-of-dense-granules",
        "name": "Abnormal number of dense granules",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-number-of-dense-granules"
      },
      {
        "slug": "enlarged-platelet-dense-granules",
        "name": "Enlarged platelet dense granules",
        "genes": 1,
        "url": "https://dantelabs.com/traits/enlarged-platelet-dense-granules"
      }
    ],
    "genes": [
      {
        "slug": "lyst",
        "symbol": "LYST",
        "hgnc": "HGNC:1968",
        "name": "lysosomal trafficking regulator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyst"
      }
    ]
  }
}