{
  "url": "https://dantelabs.com/fr/genes/zfhx4",
  "gene": {
    "slug": "zfhx4",
    "symbol": "ZFHX4",
    "name": "zinc finger homeobox 4",
    "hgnc": "HGNC:30939",
    "summary": null,
    "location": "8q21.13",
    "locusType": "gene with protein product",
    "aliases": [
      "ZFH4",
      "FLJ20980"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000091656",
    "entrezId": 79776,
    "omim": [
      "606940"
    ],
    "uniprot": [
      "Q86UP3"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "8",
      "start": 76681247,
      "end": 76867281,
      "strand": "+",
      "ensemblTranscript": "ENST00000651372.2",
      "refseqTranscript": "NM_024721.5",
      "ensemblProtein": "ENSP00000498627.1",
      "refseqProtein": "NP_078997.4",
      "exons": [
        {
          "start": 76681247,
          "end": 76681620
        },
        {
          "start": 76704043,
          "end": 76706678
        },
        {
          "start": 76707546,
          "end": 76708048
        },
        {
          "start": 76778208,
          "end": 76778439
        },
        {
          "start": 76833338,
          "end": 76833406
        },
        {
          "start": 76842655,
          "end": 76842771
        },
        {
          "start": 76848995,
          "end": 76849128
        },
        {
          "start": 76849512,
          "end": 76849712
        },
        {
          "start": 76850245,
          "end": 76850362
        },
        {
          "start": 76850886,
          "end": 76856300
        },
        {
          "start": 76863094,
          "end": 76867281
        }
      ],
      "cds": {
        "start": 76704089,
        "end": 76864565
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "8",
      "start": 77593454,
      "end": 77779521,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 76274264,
      "end": 77274263,
      "genes": [
        {
          "symbol": "PEX2",
          "ensemblId": "ENSG00000164751",
          "biotype": "protein_coding",
          "start": 76978798,
          "end": 77001044,
          "strand": "-",
          "slug": "pex2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "syndromic-complex-neurodevelopmental-disorder",
        "name": "Trouble neurodéveloppemental syndromique complexe",
        "diseases": [
          {
            "mondoId": "MONDO:0800439",
            "name": "Trouble neurodéveloppemental syndromique complexe",
            "genes": 23,
            "inheritance": null,
            "description": "Un regroupement de maladies qui partagent un retard de développement avec des signes au-delà du cerveau, chacune étant causée par des altérations d'un seul gène. Certains des gènes concernés, tels que ANKRD17, ASH1L et MYT1L, provoquent la maladie lorsqu'une seule copie est altérée, généralement de novo ; la maladie liée à AFG2A nécessite des altérations sur les deux copies.",
            "management": "Accompagnement développemental, scolaire et thérapeutique, avec un bilan des crises d'épilepsie, de la croissance, de la vue, de l'audition et des autres signes d'organes suggérés par le gène concerné. Le conseil génétique dépend du gène : test parental pour les altérations dominantes de novo, et test de porteurs pour les formes récessives.",
            "evidence": {
              "gencc": [
                "ClinGen"
              ],
              "clingen": "Strong",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/syndromic-complex-neurodevelopmental-disorder"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [],
    "related": [
      {
        "slug": "afg2a",
        "symbol": "AFG2A",
        "name": "AAA ATPase AFG2A",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/afg2a"
      },
      {
        "slug": "ankrd17",
        "symbol": "ANKRD17",
        "name": "ankyrin repeat domain 17",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/ankrd17"
      },
      {
        "slug": "ap1s2",
        "symbol": "AP1S2",
        "name": "adaptor related protein complex 1 subunit sigma 2",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/ap1s2"
      },
      {
        "slug": "ash1l",
        "symbol": "ASH1L",
        "name": "ASH1 like histone lysine methyltransferase",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/ash1l"
      },
      {
        "slug": "brpf1",
        "symbol": "BRPF1",
        "name": "bromodomain and PHD finger containing 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/brpf1"
      },
      {
        "slug": "myt1l",
        "symbol": "MYT1L",
        "name": "myelin transcription factor 1 like",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/myt1l"
      },
      {
        "slug": "nfib",
        "symbol": "NFIB",
        "name": "nuclear factor I B",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/nfib"
      },
      {
        "slug": "pan2",
        "symbol": "PAN2",
        "name": "poly(A) specific ribonuclease subunit PAN2",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/pan2"
      },
      {
        "slug": "qrich1",
        "symbol": "QRICH1",
        "name": "glutamine rich 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/qrich1"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "name": "RNA, U4 small nuclear 2",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/rnu4-2"
      },
      {
        "slug": "setd5",
        "symbol": "SETD5",
        "name": "SET domain containing 5",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/setd5"
      },
      {
        "slug": "tbck",
        "symbol": "TBCK",
        "name": "TBC1 domain containing kinase",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/tbck"
      }
    ],
    "sources": {
      "bundleId": "2026.10.19-9814e911",
      "panel": "2026-10-19",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}