{
  "url": "https://dantelabs.com/fr/genes/vim",
  "gene": {
    "slug": "vim",
    "symbol": "VIM",
    "name": "vimentin",
    "hgnc": "HGNC:12692",
    "summary": null,
    "location": "10p13",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [],
    "ensemblId": "ENSG00000026025",
    "entrezId": 7431,
    "omim": [
      "193060"
    ],
    "uniprot": [
      "P08670"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 17228241,
      "end": 17237593,
      "strand": "+",
      "ensemblTranscript": "ENST00000544301.7",
      "refseqTranscript": "NM_003380.5",
      "ensemblProtein": "ENSP00000446007.1",
      "refseqProtein": "NP_003371.2",
      "exons": [
        {
          "start": 17228241,
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        },
        {
          "start": 17229276,
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        {
          "start": 17230650,
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        {
          "start": 17233587,
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        },
        {
          "start": 17233770,
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        {
          "start": 17234693,
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        },
        {
          "start": 17235169,
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        },
        {
          "start": 17235846,
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        {
          "start": 17236294,
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        },
        {
          "start": 17237230,
          "end": 17237593
        }
      ],
      "cds": {
        "start": 17229423,
        "end": 17237271
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 17270258,
      "end": 17279592,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 16732917,
      "end": 17732916,
      "genes": [
        {
          "symbol": "RSU1",
          "ensemblId": "ENSG00000148484",
          "biotype": "protein_coding",
          "start": 16567276,
          "end": 16817603,
          "strand": "-",
          "slug": "rsu1"
        },
        {
          "symbol": "CUBN",
          "ensemblId": "ENSG00000107611",
          "biotype": "protein_coding",
          "start": 16823966,
          "end": 17129970,
          "strand": "-",
          "slug": "cubn"
        },
        {
          "symbol": "TRDMT1",
          "ensemblId": "ENSG00000107614",
          "biotype": "protein_coding",
          "start": 17137336,
          "end": 17202054,
          "strand": "-",
          "slug": "trdmt1"
        },
        {
          "symbol": "ST8SIA6",
          "ensemblId": "ENSG00000148488",
          "biotype": "protein_coding",
          "start": 17315416,
          "end": 17454681,
          "strand": "-",
          "slug": "st8sia6"
        },
        {
          "symbol": "HACD1",
          "ensemblId": "ENSG00000165996",
          "biotype": "protein_coding",
          "start": 17588301,
          "end": 17617566,
          "strand": "-",
          "slug": "hacd1"
        },
        {
          "symbol": "STAM",
          "ensemblId": "ENSG00000136738",
          "biotype": "protein_coding",
          "start": 17644124,
          "end": 17735901,
          "strand": "+",
          "slug": "stam"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-congenital-and-juvenile-cataract",
        "name": "Cataracte héréditaire congénitale et juvénile",
        "diseases": [
          {
            "mondoId": "MONDO:0011060",
            "name": "Cataracte précoce non syndromique",
            "genes": 22,
            "inheritance": null,
            "description": "Cataracte qui apparaît à la naissance ou tôt dans la vie, sans autres signes associés, causée par des modifications de gènes du cristallin tels que les cristallines (CRYAA, CRYBB2, CRYGD et d'autres), GJA3, GJA8 et MIP.",
            "management": "Un dépistage précoce et une intervention chirurgicale chez l'enfant permettent de prévenir une perte de vision permanente due à l'amblyopie, et les membres de la famille peuvent se voir proposer un examen de la vue.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/hereditary-congenital-and-juvenile-cataract"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "diffuse-nuclear-cataract",
        "name": "Diffuse nuclear cataract",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/diffuse-nuclear-cataract"
      },
      {
        "slug": "posterior-polar-cataract",
        "name": "Posterior polar cataract",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/posterior-polar-cataract"
      },
      {
        "slug": "pulverulent-cataract",
        "name": "Pulverulent cataract",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pulverulent-cataract"
      }
    ],
    "related": [
      {
        "slug": "bfsp1",
        "symbol": "BFSP1",
        "name": "beaded filament structural protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/bfsp1"
      },
      {
        "slug": "chmp4b",
        "symbol": "CHMP4B",
        "name": "charged multivesicular body protein 4B",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/chmp4b"
      },
      {
        "slug": "cryab",
        "symbol": "CRYAB",
        "name": "crystallin alpha B",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/cryab"
      },
      {
        "slug": "cryba1",
        "symbol": "CRYBA1",
        "name": "crystallin beta A1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/cryba1"
      },
      {
        "slug": "cryba2",
        "symbol": "CRYBA2",
        "name": "crystallin beta A2",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/cryba2"
      },
      {
        "slug": "cryba4",
        "symbol": "CRYBA4",
        "name": "crystallin beta A4",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/cryba4"
      },
      {
        "slug": "crybb1",
        "symbol": "CRYBB1",
        "name": "crystallin beta B1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/crybb1"
      },
      {
        "slug": "crybb3",
        "symbol": "CRYBB3",
        "name": "crystallin beta B3",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/crybb3"
      },
      {
        "slug": "crygs",
        "symbol": "CRYGS",
        "name": "crystallin gamma S",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/crygs"
      },
      {
        "slug": "epha2",
        "symbol": "EPHA2",
        "name": "EPH receptor A2",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/epha2"
      },
      {
        "slug": "gcnt2",
        "symbol": "GCNT2",
        "name": "glucosaminyl (N-acetyl) transferase 2 (I blood group)",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/gcnt2"
      },
      {
        "slug": "gja3",
        "symbol": "GJA3",
        "name": "gap junction protein alpha 3",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/gja3"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}