{
  "url": "https://dantelabs.com/fr/genes/vezf1",
  "gene": {
    "slug": "vezf1",
    "symbol": "VEZF1",
    "name": "vascular endothelial zinc finger 1",
    "hgnc": "HGNC:12949",
    "summary": null,
    "location": "17q22",
    "locusType": "gene with protein product",
    "aliases": [
      "DB1"
    ],
    "previousSymbols": [
      "ZNF161"
    ],
    "ensemblId": "ENSG00000136451",
    "entrezId": 7716,
    "omim": [
      "606747"
    ],
    "uniprot": [
      "Q14119"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 57971552,
      "end": 57988254,
      "strand": "-",
      "ensemblTranscript": "ENST00000581208.2",
      "refseqTranscript": "NM_007146.3",
      "ensemblProtein": "ENSP00000462337.1",
      "refseqProtein": "NP_009077.2",
      "exons": [
        {
          "start": 57971552,
          "end": 57974900
        },
        {
          "start": 57979152,
          "end": 57979313
        },
        {
          "start": 57980603,
          "end": 57980786
        },
        {
          "start": 57981873,
          "end": 57981936
        },
        {
          "start": 57982699,
          "end": 57983393
        },
        {
          "start": 57988079,
          "end": 57988254
        }
      ],
      "cds": {
        "start": 57974473,
        "end": 57988111
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
      "start": 56048910,
      "end": 56065620,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 57479903,
      "end": 58479902,
      "genes": [
        {
          "symbol": "MSI2",
          "ensemblId": "ENSG00000153944",
          "biotype": "protein_coding",
          "start": 57255851,
          "end": 57684689,
          "strand": "+",
          "slug": "msi2"
        },
        {
          "symbol": "CCDC182",
          "ensemblId": "ENSG00000166329",
          "biotype": "protein_coding",
          "start": 57744495,
          "end": 57745299,
          "strand": "-",
          "slug": "ccdc182"
        },
        {
          "symbol": "MRPS23",
          "ensemblId": "ENSG00000181610",
          "biotype": "protein_coding",
          "start": 57834781,
          "end": 57850076,
          "strand": "-",
          "slug": "mrps23"
        },
        {
          "symbol": "CUEDC1",
          "ensemblId": "ENSG00000180891",
          "biotype": "protein_coding",
          "start": 57861231,
          "end": 57955851,
          "strand": "-",
          "slug": "cuedc1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000266086",
          "biotype": "protein_coding",
          "start": 57989038,
          "end": 58007246,
          "strand": "-"
        },
        {
          "symbol": "SRSF1",
          "ensemblId": "ENSG00000136450",
          "biotype": "protein_coding",
          "start": 57996889,
          "end": 58007346,
          "strand": "-",
          "slug": "srsf1"
        },
        {
          "symbol": "DYNLL2",
          "ensemblId": "ENSG00000264364",
          "biotype": "protein_coding",
          "start": 58082825,
          "end": 58095542,
          "strand": "+",
          "slug": "dynll2"
        },
        {
          "symbol": "OR4D1",
          "ensemblId": "ENSG00000141194",
          "biotype": "protein_coding",
          "start": 58148384,
          "end": 58159585,
          "strand": "+",
          "slug": "or4d1"
        },
        {
          "symbol": "OR4D2",
          "ensemblId": "ENSG00000255713",
          "biotype": "protein_coding",
          "start": 58166982,
          "end": 58171411,
          "strand": "+",
          "slug": "or4d2"
        },
        {
          "symbol": "EPX",
          "ensemblId": "ENSG00000121053",
          "biotype": "protein_coding",
          "start": 58192726,
          "end": 58205174,
          "strand": "+",
          "slug": "epx"
        },
        {
          "symbol": "MKS1",
          "ensemblId": "ENSG00000011143",
          "biotype": "protein_coding",
          "start": 58205350,
          "end": 58219605,
          "strand": "-",
          "slug": "mks1"
        },
        {
          "symbol": "LPO",
          "ensemblId": "ENSG00000167419",
          "biotype": "protein_coding",
          "start": 58218548,
          "end": 58268518,
          "strand": "+",
          "slug": "lpo"
        },
        {
          "symbol": "MPO",
          "ensemblId": "ENSG00000005381",
          "biotype": "protein_coding",
          "start": 58269855,
          "end": 58280935,
          "strand": "-",
          "slug": "mpo"
        },
        {
          "symbol": "TSPOAP1",
          "ensemblId": "ENSG00000005379",
          "biotype": "protein_coding",
          "start": 58301228,
          "end": 58328823,
          "strand": "-",
          "slug": "tspoap1"
        },
        {
          "symbol": "SUPT4H1",
          "ensemblId": "ENSG00000213246",
          "biotype": "protein_coding",
          "start": 58345175,
          "end": 58353099,
          "strand": "-",
          "slug": "supt4h1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000285897",
          "biotype": "protein_coding",
          "start": 58345206,
          "end": 58417595,
          "strand": "-"
        },
        {
          "symbol": "RNF43",
          "ensemblId": "ENSG00000108375",
          "biotype": "protein_coding",
          "start": 58353671,
          "end": 58417735,
          "strand": "-",
          "slug": "rnf43"
        },
        {
          "symbol": "HSF5",
          "ensemblId": "ENSG00000176160",
          "biotype": "protein_coding",
          "start": 58420167,
          "end": 58488408,
          "strand": "-",
          "slug": "hsf5"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "arrhythmia",
        "name": "Abnormal heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/arrhythmia"
      },
      {
        "slug": "atrial-septal-defect",
        "name": "An opening in the wall separating the top two chambers of the heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/atrial-septal-defect"
      },
      {
        "slug": "congestive-heart-failure",
        "name": "Cardiac failure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/congestive-heart-failure"
      },
      {
        "slug": "emg-abnormality",
        "name": "EMG abnormality",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/emg-abnormality"
      },
      {
        "slug": "exertional-dyspnea",
        "name": "Exertional breathlessness",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/exertional-dyspnea"
      },
      {
        "slug": "premature-ventricular-contraction",
        "name": "Extra heart beat",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/premature-ventricular-contraction"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "edema",
        "name": "Fluid retention",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/edema"
      },
      {
        "slug": "left-ventricular-systolic-dysfunction",
        "name": "Left ventricular systolic dysfunction",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/left-ventricular-systolic-dysfunction"
      },
      {
        "slug": "lipoatrophy",
        "name": "Loss of fat tissue in localized area",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lipoatrophy"
      },
      {
        "slug": "myopathy",
        "name": "Muscle tissue disease",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myopathy"
      },
      {
        "slug": "orthopnea",
        "name": "Orthopnea",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/orthopnea"
      },
      {
        "slug": "reduced-left-ventricular-ejection-fraction",
        "name": "Reduced left ventricular ejection fraction",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduced-left-ventricular-ejection-fraction"
      },
      {
        "slug": "second-degree-atrioventricular-block",
        "name": "Second degree atrioventricular block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/second-degree-atrioventricular-block"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "dilated-cardiomyopathy",
        "name": "Stretched and thinned heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dilated-cardiomyopathy"
      },
      {
        "slug": "thromboembolic-stroke",
        "name": "Thromboembolic stroke",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thromboembolic-stroke"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}