{
  "url": "https://dantelabs.com/fr/genes/slitrk6",
  "gene": {
    "slug": "slitrk6",
    "symbol": "SLITRK6",
    "name": "SLIT and NTRK like family member 6",
    "hgnc": "HGNC:23503",
    "summary": null,
    "location": "13q31.1",
    "locusType": "gene with protein product",
    "aliases": [
      "FLJ22774"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000184564",
    "entrezId": 84189,
    "omim": [
      "609681"
    ],
    "uniprot": [
      "Q9H5Y7"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "13",
      "start": 85792790,
      "end": 85799419,
      "strand": "-",
      "ensemblTranscript": "ENST00000647374.2",
      "refseqTranscript": "NM_032229.3",
      "ensemblProtein": "ENSP00000495507.1",
      "refseqProtein": "NP_115605.2",
      "exons": [
        {
          "start": 85792790,
          "end": 85796532
        },
        {
          "start": 85798914,
          "end": 85799419
        }
      ],
      "cds": {
        "start": 85793983,
        "end": 85796508
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "13",
      "start": 86366925,
      "end": 86373623,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 85296105,
      "end": 86296104,
      "genes": [],
      "truncated": false
    },
    "reports": [
      {
        "slug": "high-myopia-sensorineural-deafness-slitrk6",
        "name": "Myopie forte avec surdité neurosensorielle",
        "diseases": [
          {
            "mondoId": "MONDO:0009082",
            "name": "Syndrome myopie forte-surdité neurosensorielle",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Causé par des modifications des deux copies de SLITRK6, gène qui contribue à la formation des connexions nerveuses dans l'oreille interne et influence la croissance de l'œil. Il a été rapporté dans diverses populations.",
            "management": "Un bilan auditif précoce permet d'orienter vers des appareils auditifs ou des implants cochléaires, ainsi qu'un accompagnement à la communication ; des lunettes ou des lentilles de contact corrigent la myopie, et des contrôles ophtalmologiques réguliers permettent de dépister les complications de la myopie forte. Les parents sont généralement porteurs, et un test de porteur pour les apparentés ainsi qu'un conseil génétique sont disponibles.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/high-myopia-sensorineural-deafness-slitrk6"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "high-myopia",
        "name": "Severe near sightedness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/high-myopia"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.19-9814e911",
      "panel": "2026-10-19",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}