{
  "url": "https://dantelabs.com/fr/genes/rnaset2",
  "gene": {
    "slug": "rnaset2",
    "symbol": "RNASET2",
    "name": "ribonuclease T2",
    "hgnc": "HGNC:21686",
    "summary": null,
    "location": "6q27",
    "locusType": "gene with protein product",
    "aliases": [
      "RNASE6PL",
      "FLJ10907",
      "bA514O12.3"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000026297",
    "entrezId": 8635,
    "omim": [
      "612944"
    ],
    "uniprot": [
      "O00584"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "6",
      "start": 166922113,
      "end": 166956550,
      "strand": "-",
      "ensemblTranscript": "ENST00000508775.6",
      "refseqTranscript": "NM_003730.6",
      "ensemblProtein": "ENSP00000426455.2",
      "refseqProtein": "NP_003721.2",
      "exons": [
        {
          "start": 166922113,
          "end": 166929791
        },
        {
          "start": 166931044,
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        {
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        },
        {
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        },
        {
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        },
        {
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        },
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        {
          "start": 166952488,
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        },
        {
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        }
      ],
      "cds": {
        "start": 166929588,
        "end": 166956182
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "6",
      "start": 167342992,
      "end": 167370679,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 166439332,
      "end": 167439331,
      "genes": [
        {
          "symbol": "RPS6KA2",
          "ensemblId": "ENSG00000071242",
          "biotype": "protein_coding",
          "start": 166409364,
          "end": 166906451,
          "strand": "-",
          "slug": "rps6ka2"
        },
        {
          "symbol": "RAMACL",
          "ensemblId": "ENSG00000235272",
          "biotype": "protein_coding",
          "start": 166583009,
          "end": 166586678,
          "strand": "-",
          "slug": "ramacl"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000249141",
          "biotype": "protein_coding",
          "start": 166858094,
          "end": 166956124,
          "strand": "-"
        },
        {
          "symbol": "CEP43",
          "ensemblId": "ENSG00000213066",
          "biotype": "protein_coding",
          "start": 166999174,
          "end": 167052718,
          "strand": "+",
          "slug": "cep43"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000272980",
          "biotype": "protein_coding",
          "start": 166999336,
          "end": 167139138,
          "strand": "+"
        },
        {
          "symbol": "CCR6",
          "ensemblId": "ENSG00000112486",
          "biotype": "protein_coding",
          "start": 167111790,
          "end": 167139141,
          "strand": "+",
          "slug": "ccr6"
        },
        {
          "symbol": "GPR31",
          "ensemblId": "ENSG00000120436",
          "biotype": "protein_coding",
          "start": 167155247,
          "end": 167157980,
          "strand": "-",
          "slug": "gpr31"
        },
        {
          "symbol": "UNC93A",
          "ensemblId": "ENSG00000112494",
          "biotype": "protein_coding",
          "start": 167269010,
          "end": 167316028,
          "strand": "+",
          "slug": "unc93a"
        },
        {
          "symbol": "TTLL2",
          "ensemblId": "ENSG00000120440",
          "biotype": "protein_coding",
          "start": 167325071,
          "end": 167359503,
          "strand": "+",
          "slug": "ttll2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "leukodystrophy",
        "name": "Autres leucodystrophies héréditaires",
        "diseases": [
          {
            "mondoId": "MONDO:0019046",
            "name": "Leucodystrophie (autres types et types non précisés)",
            "genes": 80,
            "inheritance": null,
            "description": "Maladies héréditaires qui altèrent ou empêchent la formation normale de la myéline, la substance blanche du cerveau et de la moelle épinière. Selon le gène concerné, les différents types suivent une hérédité autosomique récessive, autosomique dominante ou liée à l'X.",
            "management": "Connaître la cause génétique précise peut mettre fin à une recherche diagnostique, guider les soins de soutien et la surveillance, indiquer s'il existe un traitement spécifique et permettre le dépistage des apparentés.",
            "evidence": {
              "gencc": [
                "G2P",
                "Illumina",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/leukodystrophy"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-cns-myelination",
        "name": "Abnormal CNS myelination",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-cns-myelination"
      },
      {
        "slug": "cerebral-calcification",
        "name": "Abnormal deposits of calcium in the brain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cerebral-calcification"
      },
      {
        "slug": "microcephaly",
        "name": "Abnormally small head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/microcephaly"
      },
      {
        "slug": "ataxia",
        "name": "Ataxia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ataxia"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "doll-like-facies",
        "name": "Doll-like facial appearance",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/doll-like-facies"
      },
      {
        "slug": "dystonia",
        "name": "Dystonia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dystonia"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "focal-white-matter-lesions",
        "name": "Focal white matter lesions",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/focal-white-matter-lesions"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "spasticity",
        "name": "Involuntary muscle stiffness, contraction, or spasm",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/spasticity"
      },
      {
        "slug": "athetosis",
        "name": "Involuntary writhing movements in fingers, hands, toes, and feet",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/athetosis"
      },
      {
        "slug": "nystagmus",
        "name": "Involuntary, rapid, rhythmic eye movements",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nystagmus"
      },
      {
        "slug": "leukoencephalopathy",
        "name": "Leukoencephalopathy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/leukoencephalopathy"
      },
      {
        "slug": "poor-speech",
        "name": "Poor speech",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/poor-speech"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "severe-global-developmental-delay",
        "name": "Severe global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/severe-global-developmental-delay"
      },
      {
        "slug": "ventriculomegaly",
        "name": "Ventriculomegaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ventriculomegaly"
      }
    ],
    "related": [
      {
        "slug": "aars1",
        "symbol": "AARS1",
        "name": "alanyl-tRNA synthetase 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/aars1"
      },
      {
        "slug": "aars2",
        "symbol": "AARS2",
        "name": "alanyl-tRNA synthetase 2, mitochondrial",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/aars2"
      },
      {
        "slug": "abcd1",
        "symbol": "ABCD1",
        "name": "ATP binding cassette subfamily D member 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/abcd1"
      },
      {
        "slug": "acer3",
        "symbol": "ACER3",
        "name": "alkaline ceramidase 3",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/acer3"
      },
      {
        "slug": "adar",
        "symbol": "ADAR",
        "name": "adenosine deaminase RNA specific",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/adar"
      },
      {
        "slug": "aimp1",
        "symbol": "AIMP1",
        "name": "aminoacyl tRNA synthetase complex interacting multifunctional protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/aimp1"
      },
      {
        "slug": "aimp2",
        "symbol": "AIMP2",
        "name": "aminoacyl tRNA synthetase complex interacting multifunctional protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/aimp2"
      },
      {
        "slug": "aldh3a2",
        "symbol": "ALDH3A2",
        "name": "aldehyde dehydrogenase 3 family member A2",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/aldh3a2"
      },
      {
        "slug": "arsa",
        "symbol": "ARSA",
        "name": "arylsulfatase A",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/arsa"
      },
      {
        "slug": "aspa",
        "symbol": "ASPA",
        "name": "aspartoacylase",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/aspa"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/atp11a"
      },
      {
        "slug": "clcn2",
        "symbol": "CLCN2",
        "name": "chloride voltage-gated channel 2",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/clcn2"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}