{
  "url": "https://dantelabs.com/fr/genes/pnldc1",
  "gene": {
    "slug": "pnldc1",
    "symbol": "PNLDC1",
    "name": "PARN like ribonuclease domain containing exonuclease 1",
    "hgnc": "HGNC:21185",
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    "location": "6q25.3",
    "locusType": "gene with protein product",
    "aliases": [
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      "ensemblTranscript": "ENST00000392167.4",
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      "ensemblProtein": "ENSP00000376007.3",
      "refseqProtein": "NP_001258791.1",
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    },
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      "build": "GRCh37",
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      "chrom": "6",
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      "strand": "+"
    },
    "neighbourhood": {
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      "genes": [
        {
          "symbol": "SOD2",
          "ensemblId": "ENSG00000291237",
          "biotype": "protein_coding",
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          "strand": "-",
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        {
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        {
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        {
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          "biotype": "protein_coding",
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        {
          "symbol": "MRPL18",
          "ensemblId": "ENSG00000112110",
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          "strand": "+",
          "slug": "mrpl18"
        },
        {
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          "ensemblId": "ENSG00000130368",
          "biotype": "protein_coding",
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        {
          "symbol": "IGF2R",
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        {
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          "biotype": "protein_coding",
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        {
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          "slug": "slc22a2"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "male-infertility",
        "name": "Infertilité masculine",
        "diseases": [
          {
            "mondoId": "MONDO:0005372",
            "name": "Infertilité masculine",
            "genes": 41,
            "inheritance": null,
            "description": "Incapacité pour l'homme de féconder un ovocyte après une période donnée de rapports sexuels non protégés. La stérilité masculine correspond à une infertilité permanente.",
            "management": null,
            "evidence": {
              "gencc": [
                "PanelApp Australia"
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              "acmgSf": false,
              "inheritance": [
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            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/male-infertility"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-spermatogenesis",
        "name": "Abnormal sperm development",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-spermatogenesis"
      },
      {
        "slug": "azoospermia",
        "name": "Absent sperm in semen",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/azoospermia"
      },
      {
        "slug": "decreased-testicular-size",
        "name": "Decreased testicular size",
        "systems": [
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        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-testicular-size"
      },
      {
        "slug": "increased-circulating-gonadotropin-level",
        "name": "Increased circulating gonadotropin level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-gonadotropin-level"
      },
      {
        "slug": "male-infertility",
        "name": "Male infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/male-infertility"
      },
      {
        "slug": "non-obstructive-azoospermia",
        "name": "Non-obstructive azoospermia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/non-obstructive-azoospermia"
      },
      {
        "slug": "obstructive-azoospermia",
        "name": "Obstructive azoospermia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/obstructive-azoospermia"
      },
      {
        "slug": "spermatogenesis-maturation-arrest",
        "name": "Spermatogenesis maturation arrest",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/spermatogenesis-maturation-arrest"
      }
    ],
    "related": [
      {
        "slug": "actl9",
        "symbol": "ACTL9",
        "name": "actin like 9",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/actl9"
      },
      {
        "slug": "armc2",
        "symbol": "ARMC2",
        "name": "armadillo repeat containing 2",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/armc2"
      },
      {
        "slug": "aurkc",
        "symbol": "AURKC",
        "name": "aurora kinase C",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/aurkc"
      },
      {
        "slug": "bcorl1",
        "symbol": "BCORL1",
        "name": "BCL6 corepressor like 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/bcorl1"
      },
      {
        "slug": "cfap251",
        "symbol": "CFAP251",
        "name": "cilia and flagella associated protein 251",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/cfap251"
      },
      {
        "slug": "cfap43",
        "symbol": "CFAP43",
        "name": "cilia and flagella associated protein 43",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/cfap43"
      },
      {
        "slug": "dmc1",
        "symbol": "DMC1",
        "name": "DNA meiotic recombinase 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/dmc1"
      },
      {
        "slug": "dmrt1",
        "symbol": "DMRT1",
        "name": "doublesex and mab-3 related transcription factor 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/dmrt1"
      },
      {
        "slug": "dnah1",
        "symbol": "DNAH1",
        "name": "dynein axonemal heavy chain 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/dnah1"
      },
      {
        "slug": "dnah10",
        "symbol": "DNAH10",
        "name": "dynein axonemal heavy chain 10",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/dnah10"
      },
      {
        "slug": "dnah12",
        "symbol": "DNAH12",
        "name": "dynein axonemal heavy chain 12",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/dnah12"
      },
      {
        "slug": "dnah17",
        "symbol": "DNAH17",
        "name": "dynein axonemal heavy chain 17",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/dnah17"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}