{
  "url": "https://dantelabs.com/fr/genes/pml",
  "gene": {
    "slug": "pml",
    "symbol": "PML",
    "name": "PML nuclear body scaffold",
    "hgnc": "HGNC:9113",
    "summary": null,
    "location": "15q24.1",
    "locusType": "gene with protein product",
    "aliases": [
      "MYL",
      "TRIM19",
      "RNF71"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000140464",
    "entrezId": 5371,
    "omim": [
      "102578"
    ],
    "uniprot": [
      "P29590"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "15",
      "start": 73994716,
      "end": 74047827,
      "strand": "+",
      "ensemblTranscript": "ENST00000268058.8",
      "refseqTranscript": "NM_033238.3",
      "ensemblProtein": "ENSP00000268058.3",
      "refseqProtein": "NP_150241.2",
      "exons": [
        {
          "start": 73994716,
          "end": 73994941
        },
        {
          "start": 73998004,
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        {
          "start": 74022828,
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      ],
      "cds": {
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        "end": 74045008
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "15",
      "start": 74287014,
      "end": 74340153,
      "strand": "+"
    },
    "neighbourhood": {
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      "end": 74521271,
      "genes": [
        {
          "symbol": "REC114",
          "ensemblId": "ENSG00000183324",
          "biotype": "protein_coding",
          "start": 73443147,
          "end": 73560020,
          "strand": "+",
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        },
        {
          "symbol": "NPTN",
          "ensemblId": "ENSG00000156642",
          "biotype": "protein_coding",
          "start": 73546512,
          "end": 73634134,
          "strand": "-",
          "slug": "nptn"
        },
        {
          "symbol": "CD276",
          "ensemblId": "ENSG00000103855",
          "biotype": "protein_coding",
          "start": 73683966,
          "end": 73714519,
          "strand": "+",
          "slug": "cd276"
        },
        {
          "symbol": "INSYN1",
          "ensemblId": "ENSG00000205363",
          "biotype": "protein_coding",
          "start": 73735440,
          "end": 73753357,
          "strand": "-",
          "slug": "insyn1"
        },
        {
          "symbol": "TBC1D21",
          "ensemblId": "ENSG00000167139",
          "biotype": "protein_coding",
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          "end": 73889214,
          "strand": "+",
          "slug": "tbc1d21"
        },
        {
          "symbol": "LOXL1",
          "ensemblId": "ENSG00000129038",
          "biotype": "protein_coding",
          "start": 73925989,
          "end": 73952137,
          "strand": "+",
          "slug": "loxl1"
        },
        {
          "symbol": "STOML1",
          "ensemblId": "ENSG00000067221",
          "biotype": "protein_coding",
          "start": 73978926,
          "end": 73994622,
          "strand": "-",
          "slug": "stoml1"
        },
        {
          "symbol": "GOLGA6A",
          "ensemblId": "ENSG00000159289",
          "biotype": "protein_coding",
          "start": 74069857,
          "end": 74082550,
          "strand": "-",
          "slug": "golga6a"
        },
        {
          "symbol": "ISLR2",
          "ensemblId": "ENSG00000167178",
          "biotype": "protein_coding",
          "start": 74100311,
          "end": 74138540,
          "strand": "+",
          "slug": "islr2"
        },
        {
          "symbol": "ISLR",
          "ensemblId": "ENSG00000129009",
          "biotype": "protein_coding",
          "start": 74172414,
          "end": 74176872,
          "strand": "+",
          "slug": "islr"
        },
        {
          "symbol": "STRA6",
          "ensemblId": "ENSG00000137868",
          "biotype": "protein_coding",
          "start": 74179466,
          "end": 74212267,
          "strand": "-",
          "slug": "stra6"
        },
        {
          "symbol": "CCDC33",
          "ensemblId": "ENSG00000140481",
          "biotype": "protein_coding",
          "start": 74202705,
          "end": 74336472,
          "strand": "+",
          "slug": "ccdc33"
        },
        {
          "symbol": "CYP11A1",
          "ensemblId": "ENSG00000140459",
          "biotype": "protein_coding",
          "start": 74337746,
          "end": 74367884,
          "strand": "-",
          "slug": "cyp11a1"
        },
        {
          "symbol": "SEMA7A",
          "ensemblId": "ENSG00000138623",
          "biotype": "protein_coding",
          "start": 74409289,
          "end": 74433965,
          "strand": "-",
          "slug": "sema7a"
        },
        {
          "symbol": "UBL7",
          "ensemblId": "ENSG00000138629",
          "biotype": "protein_coding",
          "start": 74445187,
          "end": 74461189,
          "strand": "-",
          "slug": "ubl7"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "metrorrhagia",
        "name": "Abnormal uterus bleeding",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/metrorrhagia"
      },
      {
        "slug": "addictive-alcohol-use",
        "name": "Addictive alcohol use",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/addictive-alcohol-use"
      },
      {
        "slug": "anorexia",
        "name": "Anorexia",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anorexia"
      },
      {
        "slug": "gingival-bleeding",
        "name": "Bleeding gums",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gingival-bleeding"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "purpura",
        "name": "Blood spots",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/purpura"
      },
      {
        "slug": "epistaxis",
        "name": "Bloody nose",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/epistaxis"
      },
      {
        "slug": "bone-marrow-hypercellularity",
        "name": "Bone marrow hypercellularity",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/bone-marrow-hypercellularity"
      },
      {
        "slug": "bone-pain",
        "name": "Bone pain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bone-pain"
      },
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "chronic-infection",
        "name": "Chronic infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chronic-infection"
      },
      {
        "slug": "gangrene",
        "name": "Death of body tissue due to lack of blood flow or infection",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/gangrene"
      },
      {
        "slug": "decreased-total-leukocyte-count",
        "name": "Decreased blood leukocyte number",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-total-leukocyte-count"
      },
      {
        "slug": "diffuse-alveolar-hemorrhage",
        "name": "Diffuse alveolar hemorrhage",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diffuse-alveolar-hemorrhage"
      },
      {
        "slug": "disseminated-intravascular-coagulation",
        "name": "Disseminated intravascular coagulation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/disseminated-intravascular-coagulation"
      },
      {
        "slug": "vertigo",
        "name": "Dizziness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vertigo"
      },
      {
        "slug": "ecchymosis",
        "name": "Ecchymosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ecchymosis"
      },
      {
        "slug": "increased-total-leukocyte-count",
        "name": "Elevated white blood count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-total-leukocyte-count"
      },
      {
        "slug": "exertional-dyspnea",
        "name": "Exertional breathlessness",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/exertional-dyspnea"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "gingival-overgrowth",
        "name": "Gum enlargement",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gingival-overgrowth"
      },
      {
        "slug": "hypofibrinogenemia",
        "name": "Hypofibrinogenemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypofibrinogenemia"
      },
      {
        "slug": "stomatitis",
        "name": "Inflammation of the mouth",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/stomatitis"
      },
      {
        "slug": "pancytopenia",
        "name": "Low blood cell count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pancytopenia"
      },
      {
        "slug": "decreased-total-neutrophil-count",
        "name": "Low blood neutrophil count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-total-neutrophil-count"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "thrombocytopenia",
        "name": "Low platelet count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thrombocytopenia"
      },
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      },
      {
        "slug": "oral-cavity-bleeding",
        "name": "Oral cavity bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/oral-cavity-bleeding"
      },
      {
        "slug": "petechiae",
        "name": "Petechiae",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/petechiae"
      },
      {
        "slug": "lymphadenopathy",
        "name": "Swollen lymph nodes",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lymphadenopathy"
      },
      {
        "slug": "weight-loss",
        "name": "Weight loss",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/weight-loss"
      },
      {
        "slug": "productive-cough",
        "name": "Wet cough",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/productive-cough"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}