{
  "url": "https://dantelabs.com/fr/genes/plg",
  "gene": {
    "slug": "plg",
    "symbol": "PLG",
    "name": "plasminogen",
    "hgnc": "HGNC:9071",
    "summary": null,
    "location": "6q26",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [],
    "ensemblId": "ENSG00000122194",
    "entrezId": 5340,
    "omim": [
      "173350"
    ],
    "uniprot": [
      "P00747"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "6",
      "start": 160702244,
      "end": 160754097,
      "strand": "+",
      "ensemblTranscript": "ENST00000308192.14",
      "refseqTranscript": "NM_000301.5",
      "ensemblProtein": "ENSP00000308938.9",
      "refseqProtein": "NP_000292.1",
      "exons": [
        {
          "start": 160702244,
          "end": 160702353
        },
        {
          "start": 160706407,
          "end": 160706542
        },
        {
          "start": 160707700,
          "end": 160707806
        },
        {
          "start": 160711077,
          "end": 160711191
        },
        {
          "start": 160712986,
          "end": 160713125
        },
        {
          "start": 160714794,
          "end": 160714914
        },
        {
          "start": 160716645,
          "end": 160716763
        },
        {
          "start": 160718294,
          "end": 160718456
        },
        {
          "start": 160718693,
          "end": 160718838
        },
        {
          "start": 160722408,
          "end": 160722567
        },
        {
          "start": 160731051,
          "end": 160731232
        },
        {
          "start": 160731745,
          "end": 160731893
        },
        {
          "start": 160733995,
          "end": 160734088
        },
        {
          "start": 160736887,
          "end": 160737007
        },
        {
          "start": 160738538,
          "end": 160738612
        },
        {
          "start": 160739068,
          "end": 160739208
        },
        {
          "start": 160741311,
          "end": 160741417
        },
        {
          "start": 160752115,
          "end": 160752260
        },
        {
          "start": 160752900,
          "end": 160754097
        }
      ],
      "cds": {
        "start": 160702305,
        "end": 160753061
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "6",
      "start": 161123270,
      "end": 161174347,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 160228171,
      "end": 161228170,
      "genes": [
        {
          "symbol": "SLC22A2",
          "ensemblId": "ENSG00000112499",
          "biotype": "protein_coding",
          "start": 160171061,
          "end": 160277638,
          "strand": "-",
          "slug": "slc22a2"
        },
        {
          "symbol": "SLC22A3",
          "ensemblId": "ENSG00000146477",
          "biotype": "protein_coding",
          "start": 160348316,
          "end": 160455027,
          "strand": "+",
          "slug": "slc22a3"
        },
        {
          "symbol": "LPA",
          "ensemblId": "ENSG00000198670",
          "biotype": "protein_coding",
          "start": 160531482,
          "end": 160664276,
          "strand": "-",
          "slug": "lpa"
        },
        {
          "symbol": "MAP3K4",
          "ensemblId": "ENSG00000085511",
          "biotype": "protein_coding",
          "start": 160991344,
          "end": 161117385,
          "strand": "+",
          "slug": "map3k4"
        },
        {
          "symbol": "AGPAT4",
          "ensemblId": "ENSG00000026652",
          "biotype": "protein_coding",
          "start": 161129967,
          "end": 161274693,
          "strand": "-",
          "slug": "agpat4"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-angioedema",
        "name": "Angio-œdème héréditaire",
        "diseases": [
          {
            "mondoId": "MONDO:0019623",
            "name": "Angio-œdème héréditaire",
            "genes": 3,
            "inheritance": "autosomal-dominant",
            "description": "L'angio-œdème héréditaire (AOH) est une maladie génétique caractérisée par la survenue d'œdèmes sous-cutanés et/ou sous-muqueux transitoires et récurrents, entraînant des gonflements et/ou des douleurs abdominales.",
            "management": "Traitement de crise : concentré de C1-INH, icatibant (antagoniste des récepteurs B2) ou ecallantide ; prophylaxie : lanadelumab, garadacumab, concentré de C1-INH ; éviction des médicaments contenant des œstrogènes dans le type 3",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/hereditary-angioedema"
      },
      {
        "slug": "inherited-fibrinolytic-disorders",
        "name": "Troubles héréditaires de la fibrinolyse",
        "diseases": [
          {
            "mondoId": "MONDO:0009009",
            "name": "Déficit en plasminogène (hypoplasminogénémie)",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Causé par des modifications des deux copies de PLG, il entraîne des dépôts épais de fibrine sur les muqueuses, le plus souvent sur les paupières (conjonctivite ligneuse), mais aussi sur les gencives et dans les voies respiratoires.",
            "management": "Un traitement substitutif par plasminogène est disponible et peut éliminer les dépôts.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/inherited-fibrinolytic-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-fallopian-tube-morphology",
        "name": "Abnormal fallopian tube morphology",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-fallopian-tube-morphology"
      },
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "systems": [],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      },
      {
        "slug": "abnormality-of-the-middle-ear",
        "name": "Abnormality of the middle ear",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-middle-ear"
      },
      {
        "slug": "abnormality-of-the-ovary",
        "name": "Abnormality of the ovary",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ovary"
      },
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "systems": [],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      },
      {
        "slug": "abnormality-of-the-skin",
        "name": "Abnormality of the skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-skin"
      },
      {
        "slug": "abnormality-of-vision",
        "name": "Abnormality of vision",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-vision"
      },
      {
        "slug": "angioedema",
        "name": "Angioedema",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/angioedema"
      },
      {
        "slug": "macrocephaly",
        "name": "Big calvaria",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/macrocephaly"
      },
      {
        "slug": "blindness",
        "name": "Blindness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/blindness"
      },
      {
        "slug": "dandy-walker-malformation",
        "name": "Dandy-Walker malformation",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dandy-walker-malformation"
      },
      {
        "slug": "decreased-circulating-plasminogen-concentration",
        "name": "Decreased circulating plasminogen concentration",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-plasminogen-concentration"
      },
      {
        "slug": "duodenal-ulcer",
        "name": "Duodenal ulcer",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/duodenal-ulcer"
      },
      {
        "slug": "facial-edema",
        "name": "Facial puffiness",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/facial-edema"
      },
      {
        "slug": "generalized-hypotonia",
        "name": "Generalized decreased muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/generalized-hypotonia"
      },
      {
        "slug": "periodontitis",
        "name": "Gum disease",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/periodontitis"
      },
      {
        "slug": "gingival-overgrowth",
        "name": "Gum enlargement",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gingival-overgrowth"
      },
      {
        "slug": "gingivitis",
        "name": "Inflamed gums",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gingivitis"
      },
      {
        "slug": "nephritis",
        "name": "Kidney inflammation",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nephritis"
      },
      {
        "slug": "kidney-stone",
        "name": "Kidney stone",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/kidney-stone"
      },
      {
        "slug": "laryngeal-edema",
        "name": "Laryngeal edema",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/laryngeal-edema"
      },
      {
        "slug": "conjunctivitis",
        "name": "Pink eye",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/conjunctivitis"
      },
      {
        "slug": "recurrent-upper-respiratory-tract-infections",
        "name": "Recurrent colds",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/recurrent-upper-respiratory-tract-infections"
      },
      {
        "slug": "cerebellar-hypoplasia",
        "name": "Small cerebellum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cerebellar-hypoplasia"
      },
      {
        "slug": "swollen-lip",
        "name": "Swollen lip",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/swollen-lip"
      },
      {
        "slug": "hydrocephalus",
        "name": "Too much cerebrospinal fluid in the brain",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hydrocephalus"
      },
      {
        "slug": "cervicitis",
        "name": "Uterine cervix inflammation",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cervicitis"
      },
      {
        "slug": "ventriculomegaly",
        "name": "Ventriculomegaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ventriculomegaly"
      }
    ],
    "related": [
      {
        "slug": "f12",
        "symbol": "F12",
        "name": "coagulation factor XII",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/f12"
      },
      {
        "slug": "serping1",
        "symbol": "SERPING1",
        "name": "serpin family G member 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/serping1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}