{
  "url": "https://dantelabs.com/fr/genes/kcnn4",
  "gene": {
    "slug": "kcnn4",
    "symbol": "KCNN4",
    "name": "potassium calcium-activated channel subfamily N member 4",
    "hgnc": "HGNC:6293",
    "summary": null,
    "location": "19q13.31",
    "locusType": "gene with protein product",
    "aliases": [
      "KCa3.1",
      "hSK4",
      "hKCa4",
      "hIKCa1",
      "IK"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000104783",
    "entrezId": 3783,
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      "602754"
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    "uniprot": [
      "O15554"
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      "strand": "-",
      "ensemblTranscript": "ENST00000648319.1",
      "refseqTranscript": "NM_002250.3",
      "ensemblProtein": "ENSP00000496939.1",
      "refseqProtein": "NP_002241.1",
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    },
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        {
          "symbol": "CD177",
          "ensemblId": "ENSG00000204936",
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        {
          "symbol": "TEX101",
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        {
          "symbol": "LYPD3",
          "ensemblId": "ENSG00000124466",
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        {
          "symbol": "PHLDB3",
          "ensemblId": "ENSG00000176531",
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          "strand": "-",
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        {
          "symbol": "ETHE1",
          "ensemblId": "ENSG00000105755",
          "biotype": "protein_coding",
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        {
          "symbol": "ZNF575",
          "ensemblId": "ENSG00000176472",
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        },
        {
          "symbol": "XRCC1",
          "ensemblId": "ENSG00000073050",
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          "start": 43543306,
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          "strand": "-",
          "slug": "xrcc1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000268361",
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        },
        {
          "symbol": "PINLYP",
          "ensemblId": "ENSG00000234465",
          "biotype": "protein_coding",
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        {
          "symbol": "IRGQ",
          "ensemblId": "ENSG00000167378",
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        {
          "symbol": "ZNF576",
          "ensemblId": "ENSG00000124444",
          "biotype": "protein_coding",
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          "slug": "znf576"
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        {
          "symbol": "SRRM5",
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          "biotype": "protein_coding",
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        {
          "symbol": "ZNF428",
          "ensemblId": "ENSG00000131116",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "znf428"
        },
        {
          "symbol": "CADM4",
          "ensemblId": "ENSG00000105767",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "cadm4"
        },
        {
          "symbol": "PLAUR",
          "ensemblId": "ENSG00000011422",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "plaur"
        },
        {
          "symbol": "IRGC",
          "ensemblId": "ENSG00000124449",
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          "slug": "irgc"
        },
        {
          "symbol": "SMG9",
          "ensemblId": "ENSG00000105771",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "smg9"
        },
        {
          "symbol": "LYPD5",
          "ensemblId": "ENSG00000159871",
          "biotype": "protein_coding",
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          "slug": "lypd5"
        },
        {
          "symbol": "ZNF283",
          "ensemblId": "ENSG00000167637",
          "biotype": "protein_coding",
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          "slug": "znf283"
        },
        {
          "symbol": "ZNF404",
          "ensemblId": "ENSG00000176222",
          "biotype": "protein_coding",
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          "slug": "znf404"
        },
        {
          "symbol": "ZNF45",
          "ensemblId": "ENSG00000124459",
          "biotype": "protein_coding",
          "start": 43910549,
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          "strand": "-",
          "slug": "znf45"
        },
        {
          "symbol": "ZNF221",
          "ensemblId": "ENSG00000159905",
          "biotype": "protein_coding",
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          "slug": "znf221"
        },
        {
          "symbol": "ZNF155",
          "ensemblId": "ENSG00000204920",
          "biotype": "protein_coding",
          "start": 43967862,
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          "strand": "+",
          "slug": "znf155"
        },
        {
          "symbol": "ZNF230",
          "ensemblId": "ENSG00000159882",
          "biotype": "protein_coding",
          "start": 44002934,
          "end": 44013924,
          "strand": "+",
          "slug": "znf230"
        },
        {
          "symbol": "ZNF222",
          "ensemblId": "ENSG00000159885",
          "biotype": "protein_coding",
          "start": 44025326,
          "end": 44033222,
          "strand": "+",
          "slug": "znf222"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000267022",
          "biotype": "protein_coding",
          "start": 44025354,
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          "strand": "+"
        },
        {
          "symbol": "ZNF223",
          "ensemblId": "ENSG00000178386",
          "biotype": "protein_coding",
          "start": 44051367,
          "end": 44069308,
          "strand": "+",
          "slug": "znf223"
        },
        {
          "symbol": "ZNF284",
          "ensemblId": "ENSG00000186026",
          "biotype": "protein_coding",
          "start": 44072138,
          "end": 44089613,
          "strand": "+",
          "slug": "znf284"
        },
        {
          "symbol": "ZNF224",
          "ensemblId": "ENSG00000267680",
          "biotype": "protein_coding",
          "start": 44094326,
          "end": 44111682,
          "strand": "+",
          "slug": "znf224"
        },
        {
          "symbol": "ZNF225",
          "ensemblId": "ENSG00000256294",
          "biotype": "protein_coding",
          "start": 44112181,
          "end": 44135473,
          "strand": "+",
          "slug": "znf225"
        },
        {
          "symbol": "ZNF234",
          "ensemblId": "ENSG00000263002",
          "biotype": "protein_coding",
          "start": 44141355,
          "end": 44160839,
          "strand": "+",
          "slug": "znf234"
        },
        {
          "symbol": "ZNF226",
          "ensemblId": "ENSG00000167380",
          "biotype": "protein_coding",
          "start": 44165069,
          "end": 44178381,
          "strand": "+",
          "slug": "znf226"
        },
        {
          "symbol": "ZNF227",
          "ensemblId": "ENSG00000131115",
          "biotype": "protein_coding",
          "start": 44207475,
          "end": 44238179,
          "strand": "+",
          "slug": "znf227"
        },
        {
          "symbol": "ZNF235",
          "ensemblId": "ENSG00000159917",
          "biotype": "protein_coding",
          "start": 44228729,
          "end": 44305046,
          "strand": "-",
          "slug": "znf235"
        },
        {
          "symbol": "ZNF233",
          "ensemblId": "ENSG00000159915",
          "biotype": "protein_coding",
          "start": 44259863,
          "end": 44277043,
          "strand": "+",
          "slug": "znf233"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "red-blood-cell-membrane-disorders",
        "name": "Troubles de la membrane des globules rouges",
        "diseases": [
          {
            "mondoId": "MONDO:0020102",
            "name": "Stomatocytose héréditaire",
            "genes": 5,
            "inheritance": "autosomal-dominant",
            "description": "Groupe de maladies dans lesquelles les globules rouges perdent ou gagnent de l'eau et des sels, notamment la stomatocytose héréditaire déshydratée (PIEZO1, KCNN4), la stomatocytose hyperhydratée (RHAG), l'ovalocytose d'Asie du Sud-Est et le syndrome de déficience Rh, provoquant une anémie hémolytique d'intensité variable et parfois une surcharge en fer.",
            "management": "Il convient d'éviter l'ablation de la rate, car elle augmente le risque de caillots sanguins graves dans ces maladies.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/red-blood-cell-membrane-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-circulating-potassium-concentration",
        "name": "Abnormal circulating potassium concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-potassium-concentration"
      },
      {
        "slug": "abnormality-of-the-liver",
        "name": "Abnormality of the liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-liver"
      },
      {
        "slug": "absent-vas-deferens",
        "name": "Absent vas deferens",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/absent-vas-deferens"
      },
      {
        "slug": "acanthocytosis",
        "name": "Acanthocytosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/acanthocytosis"
      },
      {
        "slug": "gastroesophageal-reflux",
        "name": "Acid reflux",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gastroesophageal-reflux"
      },
      {
        "slug": "anemia-of-inadequate-production",
        "name": "Anemia of inadequate production",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anemia-of-inadequate-production"
      },
      {
        "slug": "anisopoikilocytosis",
        "name": "Anisopoikilocytosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anisopoikilocytosis"
      },
      {
        "slug": "anxiety",
        "name": "Anxiety",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anxiety"
      },
      {
        "slug": "asthma",
        "name": "Asthma",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/asthma"
      },
      {
        "slug": "bite-cells",
        "name": "Bite cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bite-cells"
      },
      {
        "slug": "portal-vein-thrombosis",
        "name": "Blood clot in portal vein",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/portal-vein-thrombosis"
      },
      {
        "slug": "pneumothorax",
        "name": "Collapsed lung",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/pneumothorax"
      },
      {
        "slug": "congenital-hemolytic-anemia",
        "name": "Congenital hemolytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/congenital-hemolytic-anemia"
      },
      {
        "slug": "hemoptysis",
        "name": "Coughing up blood",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hemoptysis"
      },
      {
        "slug": "decreased-body-mass-index",
        "name": "Decreased body mass index",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-body-mass-index"
      },
      {
        "slug": "depression",
        "name": "Depression",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/depression"
      },
      {
        "slug": "increased-circulating-ferritin-concentration",
        "name": "Elevated serum ferritin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-ferritin-concentration"
      },
      {
        "slug": "elevated-sweat-chloride",
        "name": "Elevated sweat chloride",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-sweat-chloride"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "episodic-fatigue",
        "name": "Episodic fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/episodic-fatigue"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "steatorrhea",
        "name": "Fat in feces",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/steatorrhea"
      },
      {
        "slug": "edema",
        "name": "Fluid retention",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/edema"
      },
      {
        "slug": "cholelithiasis",
        "name": "Gallstones",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cholelithiasis"
      },
      {
        "slug": "hearing-impairment",
        "name": "Hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hearing-impairment"
      },
      {
        "slug": "hemolytic-anemia",
        "name": "Hemolytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hemolytic-anemia"
      },
      {
        "slug": "increased-total-bilirubin",
        "name": "High bili total",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-total-bilirubin"
      },
      {
        "slug": "hyperbilirubinemia",
        "name": "High blood bilirubin levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/hyperbilirubinemia"
      },
      {
        "slug": "elevated-circulating-hepatic-transaminase-concentration",
        "name": "High liver enzymes",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/elevated-circulating-hepatic-transaminase-concentration"
      },
      {
        "slug": "hypochromia",
        "name": "Hypochromia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypochromia"
      },
      {
        "slug": "exocrine-pancreatic-insufficiency",
        "name": "Inability to properly digest food due to lack of pancreatic digestive enzymes",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/exocrine-pancreatic-insufficiency"
      },
      {
        "slug": "increased-circulating-hemoglobin-concentration",
        "name": "Increased circulating hemoglobin concentration",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-circulating-hemoglobin-concentration"
      },
      {
        "slug": "increased-circulating-lactate-dehydrogenase-concentration",
        "name": "Increased circulating lactate dehydrogenase concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-lactate-dehydrogenase-concentration"
      },
      {
        "slug": "reticulocytosis",
        "name": "Increased immature red blood cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reticulocytosis"
      },
      {
        "slug": "increased-mean-corpuscular-hemoglobin-concentration",
        "name": "Increased mean corpuscular hemoglobin concentration",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-mean-corpuscular-hemoglobin-concentration"
      },
      {
        "slug": "increased-mean-corpuscular-volume",
        "name": "Increased mean corpuscular volume",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-mean-corpuscular-volume"
      },
      {
        "slug": "thrombocytosis",
        "name": "Increased number of platelets in blood",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thrombocytosis"
      },
      {
        "slug": "polycythemia",
        "name": "Increased red blood cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/polycythemia"
      },
      {
        "slug": "increased-red-cell-osmotic-fragility",
        "name": "Increased red cell osmotic fragility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-red-cell-osmotic-fragility"
      },
      {
        "slug": "splenomegaly",
        "name": "Increased spleen size",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/splenomegaly"
      },
      {
        "slug": "intermittent-jaundice",
        "name": "Intermittent yellow skin",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intermittent-jaundice"
      },
      {
        "slug": "jaundice",
        "name": "Jaundice",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/jaundice"
      },
      {
        "slug": "kidney-stone",
        "name": "Kidney stone",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/kidney-stone"
      },
      {
        "slug": "macrocytic-anemia",
        "name": "Macrocytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/macrocytic-anemia"
      },
      {
        "slug": "malabsorption",
        "name": "Malabsorption",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/malabsorption"
      },
      {
        "slug": "male-infertility",
        "name": "Male infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/male-infertility"
      },
      {
        "slug": "meconium-ileus",
        "name": "Meconium ileus",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/meconium-ileus"
      },
      {
        "slug": "nasal-polyposis",
        "name": "Nasal polyposis",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/nasal-polyposis"
      },
      {
        "slug": "neonatal-hyperbilirubinemia",
        "name": "Neonatal hyperbilirubinemia",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neonatal-hyperbilirubinemia"
      },
      {
        "slug": "nonspherocytic-hemolytic-anemia",
        "name": "Nonspherocytic hemolytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/nonspherocytic-hemolytic-anemia"
      },
      {
        "slug": "nontuberculous-mycobacterial-pulmonary-infection",
        "name": "Nontuberculous mycobacterial pulmonary infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/nontuberculous-mycobacterial-pulmonary-infection"
      },
      {
        "slug": "airway-obstruction",
        "name": "Obstructive lung disease",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/airway-obstruction"
      },
      {
        "slug": "osteopenia",
        "name": "Osteopenia",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/osteopenia"
      },
      {
        "slug": "osteoporosis",
        "name": "Osteoporosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/osteoporosis"
      },
      {
        "slug": "bronchiectasis",
        "name": "Permanent enlargement of the airways of the lungs",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/bronchiectasis"
      },
      {
        "slug": "pulmonary-venous-hypertension",
        "name": "Pulmonary venous hypertension",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/pulmonary-venous-hypertension"
      },
      {
        "slug": "rectal-prolapse",
        "name": "Rectum protrudes through anus",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/rectal-prolapse"
      },
      {
        "slug": "recurrent-aspergillus-infection",
        "name": "Recurrent Aspergillus infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-aspergillus-infection"
      },
      {
        "slug": "recurrent-burkholderia-cepacia-infection",
        "name": "Recurrent Burkholderia cepacia infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/recurrent-burkholderia-cepacia-infection"
      },
      {
        "slug": "recurrent-lower-respiratory-tract-infections",
        "name": "Recurrent chest infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-lower-respiratory-tract-infections"
      },
      {
        "slug": "recurrent-haemophilus-influenzae-infection",
        "name": "Recurrent Haemophilus influenzae infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-haemophilus-influenzae-infection"
      },
      {
        "slug": "recurrent-respiratory-infections",
        "name": "Recurrent respiratory infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-respiratory-infections"
      },
      {
        "slug": "recurrent-staphylococcus-aureus-infection",
        "name": "Recurrent Staphylococcus aureus infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-staphylococcus-aureus-infection"
      },
      {
        "slug": "reduced-forced-expiratory-volume-in-one-second",
        "name": "Reduced forced expiratory volume in one second",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/reduced-forced-expiratory-volume-in-one-second"
      },
      {
        "slug": "cirrhosis",
        "name": "Scar tissue replaces healthy tissue in the liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/cirrhosis"
      },
      {
        "slug": "schistocytosis",
        "name": "Schistocytosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/schistocytosis"
      },
      {
        "slug": "sinusitis",
        "name": "Sinus disease",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sinusitis"
      },
      {
        "slug": "thromboembolism",
        "name": "Thromboembolism",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thromboembolism"
      }
    ],
    "related": [
      {
        "slug": "piezo1",
        "symbol": "PIEZO1",
        "name": "piezo type mechanosensitive ion channel component 1 (Er blood group)",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/piezo1"
      },
      {
        "slug": "rhag",
        "symbol": "RHAG",
        "name": "Rh associated glycoprotein",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/rhag"
      },
      {
        "slug": "rhce",
        "symbol": "RHCE",
        "name": "Rh blood group CcEe antigens",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/rhce"
      },
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/slc4a1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}