{
  "url": "https://dantelabs.com/fr/genes/itgb6",
  "gene": {
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    "symbol": "ITGB6",
    "name": "integrin subunit beta 6",
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    "location": "2q24.2",
    "locusType": "gene with protein product",
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        {
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        {
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        {
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      ],
      "truncated": false
    },
    "reports": [
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        "slug": "amelogenesis-imperfecta",
        "name": "Amélogenèse imparfaite",
        "diseases": [
          {
            "mondoId": "MONDO:0019507",
            "name": "amélogenèse imparfaite",
            "genes": 17,
            "inheritance": "autosomal-dominant",
            "description": null,
            "management": null,
            "evidence": {
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                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
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              "acmgSf": false,
              "inheritance": [
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            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/amelogenesis-imperfecta"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
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        "name": "Abnormal of nasal shape",
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        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-nasal-morphology"
      },
      {
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        "name": "Abnormally shaped skeletal",
        "systems": [
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        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-skeletal-morphology"
      },
      {
        "slug": "microcephaly",
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          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/microcephaly"
      },
      {
        "slug": "anterior-open-bite-malocclusion",
        "name": "Absence of overlap of anterior upper and lower teeth",
        "systems": [
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        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anterior-open-bite-malocclusion"
      },
      {
        "slug": "amelogenesis-imperfecta",
        "name": "Amelogenesis imperfecta",
        "systems": [
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          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/amelogenesis-imperfecta"
      },
      {
        "slug": "delayed-skeletal-maturation",
        "name": "Delayed bone maturation",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/delayed-skeletal-maturation"
      },
      {
        "slug": "dental-enamel-pits",
        "name": "Dental enamel pits",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/dental-enamel-pits"
      },
      {
        "slug": "eeg-abnormality",
        "name": "EEG abnormality",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/eeg-abnormality"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "photophobia",
        "name": "Extreme sensitivity of the eyes to light",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/photophobia"
      },
      {
        "slug": "flexion-contracture",
        "name": "Flexed joint that cannot be straightened",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/flexion-contracture"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "alopecia",
        "name": "Hair loss",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/alopecia"
      },
      {
        "slug": "hearing-impairment",
        "name": "Hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hearing-impairment"
      },
      {
        "slug": "hypergonadotropic-hypogonadism",
        "name": "Hypergonadotropic hypogonadism",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypergonadotropic-hypogonadism"
      },
      {
        "slug": "hyperkeratosis",
        "name": "Hyperkeratosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyperkeratosis"
      },
      {
        "slug": "ichthyosis",
        "name": "Ichthyosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ichthyosis"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "macrotia",
        "name": "Large ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/macrotia"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "short-corpus-callosum",
        "name": "Short corpus callosum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-corpus-callosum"
      },
      {
        "slug": "brachydactyly",
        "name": "Short fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/brachydactyly"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "sparse-body-hair",
        "name": "Sparse body hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-body-hair"
      },
      {
        "slug": "sparse-hair",
        "name": "Sparse hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sparse-hair"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-eyebrow",
        "name": "Sparse or absent eyebrows",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-eyebrow"
      },
      {
        "slug": "sparse-scalp-hair",
        "name": "Sparse scalp hair",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-scalp-hair"
      },
      {
        "slug": "split-hand",
        "name": "Split hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/split-hand"
      },
      {
        "slug": "enamel-hypoplasia",
        "name": "Thin dental enamel",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/enamel-hypoplasia"
      },
      {
        "slug": "yellow-brown-discoloration-of-the-teeth",
        "name": "Yellow-brown discoloration of the teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/yellow-brown-discoloration-of-the-teeth"
      }
    ],
    "related": [
      {
        "slug": "acp4",
        "symbol": "ACP4",
        "name": "acid phosphatase 4",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/acp4"
      },
      {
        "slug": "ambn",
        "symbol": "AMBN",
        "name": "ameloblastin",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/ambn"
      },
      {
        "slug": "amelx",
        "symbol": "AMELX",
        "name": "amelogenin X-linked",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/amelx"
      },
      {
        "slug": "dlx3",
        "symbol": "DLX3",
        "name": "distal-less homeobox 3",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/dlx3"
      },
      {
        "slug": "enam",
        "symbol": "ENAM",
        "name": "enamelin",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/enam"
      },
      {
        "slug": "fam20a",
        "symbol": "FAM20A",
        "name": "FAM20A golgi associated secretory pathway pseudokinase",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/fam20a"
      },
      {
        "slug": "gpr68",
        "symbol": "GPR68",
        "name": "G protein-coupled receptor 68",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/gpr68"
      },
      {
        "slug": "klk4",
        "symbol": "KLK4",
        "name": "kallikrein related peptidase 4",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/klk4"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "name": "laminin subunit beta 3",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/lamb3"
      },
      {
        "slug": "mmp20",
        "symbol": "MMP20",
        "name": "matrix metallopeptidase 20",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/mmp20"
      },
      {
        "slug": "odaph",
        "symbol": "ODAPH",
        "name": "odontogenesis associated phosphoprotein",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/odaph"
      },
      {
        "slug": "relt",
        "symbol": "RELT",
        "name": "RELT TNF receptor",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/relt"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}