{
  "url": "https://dantelabs.com/fr/genes/irs4",
  "gene": {
    "slug": "irs4",
    "symbol": "IRS4",
    "name": "insulin receptor substrate 4",
    "hgnc": "HGNC:6128",
    "summary": null,
    "location": "Xq22.3",
    "locusType": "gene with protein product",
    "aliases": [
      "PY160",
      "IRS-4"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000133124",
    "entrezId": 8471,
    "omim": [
      "300904"
    ],
    "uniprot": [
      "O14654"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "X",
      "start": 108719946,
      "end": 108736563,
      "strand": "-",
      "ensemblTranscript": "ENST00000372129.4",
      "refseqTranscript": "NM_001379150.1",
      "ensemblProtein": "ENSP00000361202.3",
      "refseqProtein": "NP_001366079.1",
      "exons": [
        {
          "start": 108719946,
          "end": 108722523
        },
        {
          "start": 108732579,
          "end": 108736563
        }
      ],
      "cds": {
        "start": 108722519,
        "end": 108736344
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "X",
      "start": 107975712,
      "end": 107979651,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 108228255,
      "end": 109228254,
      "genes": [
        {
          "symbol": "COL4A6",
          "ensemblId": "ENSG00000197565",
          "biotype": "protein_coding",
          "start": 108155297,
          "end": 108439497,
          "strand": "-",
          "slug": "col4a6"
        },
        {
          "symbol": "COL4A5",
          "ensemblId": "ENSG00000188153",
          "biotype": "protein_coding",
          "start": 108439717,
          "end": 108697766,
          "strand": "+",
          "slug": "col4a5"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "congenital-hypothyroidism",
        "name": "Hypothyroïdie congénitale",
        "diseases": [
          {
            "mondoId": "MONDO:0018612",
            "name": "Hypothyroïdie congénitale",
            "genes": 18,
            "inheritance": null,
            "description": "Un déficit en hormones thyroïdiennes présent dès la naissance.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/congenital-hypothyroidism"
      },
      {
        "slug": "thyroid-cancer-report",
        "name": "Cancer de la thyroïde",
        "diseases": [
          {
            "mondoId": "MONDO:0005420",
            "name": "Hypothyroïdie",
            "genes": 18,
            "inheritance": null,
            "description": "Taux anormalement bas d'hormones thyroïdiennes.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0003240",
            "name": "Trouble de la glande thyroïde",
            "genes": 21,
            "inheritance": null,
            "description": "Une affection touchant la glande thyroïde.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/thyroid-cancer-report"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "central-hypothyroidism",
        "name": "Central hypothyroidism",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/central-hypothyroidism"
      },
      {
        "slug": "decreased-circulating-free-t4-concentration",
        "name": "Decreased circulating free T4 concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/decreased-circulating-free-t4-concentration"
      },
      {
        "slug": "inappropriately-normal-thyroid-stimulating-hormone-level",
        "name": "Inappropriately normal thyroid-stimulating hormone level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/inappropriately-normal-thyroid-stimulating-hormone-level"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "thyroid-hypoplasia",
        "name": "Small thyroid gland",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thyroid-hypoplasia"
      }
    ],
    "related": [
      {
        "slug": "duox2",
        "symbol": "DUOX2",
        "name": "dual oxidase 2",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/duox2"
      },
      {
        "slug": "duoxa2",
        "symbol": "DUOXA2",
        "name": "dual oxidase maturation factor 2",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/duoxa2"
      },
      {
        "slug": "igsf1",
        "symbol": "IGSF1",
        "name": "immunoglobulin superfamily member 1",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/igsf1"
      },
      {
        "slug": "iyd",
        "symbol": "IYD",
        "name": "iodotyrosine deiodinase",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/iyd"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "name": "NK2 homeobox 5",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/nkx2-5"
      },
      {
        "slug": "pax8",
        "symbol": "PAX8",
        "name": "paired box 8",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/pax8"
      },
      {
        "slug": "secisbp2",
        "symbol": "SECISBP2",
        "name": "SECIS binding protein 2",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/secisbp2"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "name": "solute carrier family 26 member 4",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/slc26a4"
      },
      {
        "slug": "slc26a7",
        "symbol": "SLC26A7",
        "name": "solute carrier family 26 member 7",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/slc26a7"
      },
      {
        "slug": "slc5a5",
        "symbol": "SLC5A5",
        "name": "solute carrier family 5 member 5",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/slc5a5"
      },
      {
        "slug": "tbl1x",
        "symbol": "TBL1X",
        "name": "transducin beta like 1 X-linked",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/tbl1x"
      },
      {
        "slug": "tg",
        "symbol": "TG",
        "name": "thyroglobulin",
        "shared": 3,
        "url": "https://dantelabs.com/fr/genes/tg"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}