{
  "url": "https://dantelabs.com/fr/genes/irs1",
  "gene": {
    "slug": "irs1",
    "symbol": "IRS1",
    "name": "insulin receptor substrate 1",
    "hgnc": "HGNC:6125",
    "summary": null,
    "location": "2q36.3",
    "locusType": "gene with protein product",
    "aliases": [
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    "previousSymbols": [],
    "ensemblId": "ENSG00000169047",
    "entrezId": 3667,
    "omim": [
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    ],
    "uniprot": [
      "P35568"
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    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "2",
      "start": 226731312,
      "end": 226799820,
      "strand": "-",
      "ensemblTranscript": "ENST00000305123.6",
      "refseqTranscript": "NM_005544.3",
      "ensemblProtein": "ENSP00000304895.4",
      "refseqProtein": "NP_005535.1",
      "exons": [
        {
          "start": 226731312,
          "end": 226736250
        },
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          "end": 226799820
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      ],
      "cds": {
        "start": 226795010,
        "end": 226798738
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "2",
      "start": 227596033,
      "end": 227664475,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 226265566,
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      "genes": [
        {
          "symbol": "RHBDD1",
          "ensemblId": "ENSG00000144468",
          "biotype": "protein_coding",
          "start": 226835581,
          "end": 227001006,
          "strand": "+",
          "slug": "rhbdd1"
        },
        {
          "symbol": "COL4A4",
          "ensemblId": "ENSG00000081052",
          "biotype": "protein_coding",
          "start": 227002713,
          "end": 227164559,
          "strand": "-",
          "slug": "col4a4"
        },
        {
          "symbol": "COL4A3",
          "ensemblId": "ENSG00000169031",
          "biotype": "protein_coding",
          "start": 227164509,
          "end": 227314792,
          "strand": "+",
          "slug": "col4a3"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "insulin-resistance",
        "name": "Body fails to respond to insulin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/insulin-resistance"
      },
      {
        "slug": "increased-waist-to-hip-ratio",
        "name": "Increased waist to hip ratio",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/increased-waist-to-hip-ratio"
      },
      {
        "slug": "type-ii-diabetes-mellitus",
        "name": "Noninsulin-dependent diabetes",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/type-ii-diabetes-mellitus"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}