{
  "url": "https://dantelabs.com/fr/genes/il37",
  "gene": {
    "slug": "il37",
    "symbol": "IL37",
    "name": "interleukin 37",
    "hgnc": "HGNC:15563",
    "summary": null,
    "location": "2q14.1",
    "locusType": "gene with protein product",
    "aliases": [
      "FIL1",
      "FIL1Z",
      "FIL1(ZETA)",
      "IL-1H4",
      "IL-1RP1",
      "IL-1F7"
    ],
    "previousSymbols": [
      "IL1F7"
    ],
    "ensemblId": "ENSG00000125571",
    "entrezId": 27178,
    "omim": [
      "605510"
    ],
    "uniprot": [
      "Q9NZH6"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "2",
      "start": 112911165,
      "end": 112918882,
      "strand": "+",
      "ensemblTranscript": "ENST00000263326.8",
      "refseqTranscript": "NM_014439.4",
      "ensemblProtein": "ENSP00000263326.3",
      "refseqProtein": "NP_055254.2",
      "exons": [
        {
          "start": 112911165,
          "end": 112911248
        },
        {
          "start": 112912963,
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        {
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        {
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      ],
      "cds": {
        "start": 112913013,
        "end": 112918809
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "2",
      "start": 113670548,
      "end": 113676459,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 112415024,
      "end": 113415023,
      "genes": [
        {
          "symbol": "RGPD8",
          "ensemblId": "ENSG00000169629",
          "biotype": "protein_coding",
          "start": 112368369,
          "end": 112434488,
          "strand": "-",
          "slug": "rgpd8"
        },
        {
          "symbol": "TTL",
          "ensemblId": "ENSG00000114999",
          "biotype": "protein_coding",
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          "end": 112541739,
          "strand": "+",
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        },
        {
          "symbol": "POLR1B",
          "ensemblId": "ENSG00000125630",
          "biotype": "protein_coding",
          "start": 112541915,
          "end": 112579818,
          "strand": "+",
          "slug": "polr1b"
        },
        {
          "symbol": "CHCHD5",
          "ensemblId": "ENSG00000125611",
          "biotype": "protein_coding",
          "start": 112584240,
          "end": 112589275,
          "strand": "+",
          "slug": "chchd5"
        },
        {
          "symbol": "SLC20A1",
          "ensemblId": "ENSG00000144136",
          "biotype": "protein_coding",
          "start": 112645853,
          "end": 112664727,
          "strand": "+",
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        },
        {
          "symbol": "NT5DC4",
          "ensemblId": "ENSG00000144130",
          "biotype": "protein_coding",
          "start": 112721020,
          "end": 112742879,
          "strand": "+",
          "slug": "nt5dc4"
        },
        {
          "symbol": "CKAP2L",
          "ensemblId": "ENSG00000169607",
          "biotype": "protein_coding",
          "start": 112736349,
          "end": 112764664,
          "strand": "-",
          "slug": "ckap2l"
        },
        {
          "symbol": "IL1A",
          "ensemblId": "ENSG00000115008",
          "biotype": "protein_coding",
          "start": 112773916,
          "end": 112784500,
          "strand": "-",
          "slug": "il1a"
        },
        {
          "symbol": "IL1B",
          "ensemblId": "ENSG00000125538",
          "biotype": "protein_coding",
          "start": 112829750,
          "end": 112864235,
          "strand": "-",
          "slug": "il1b"
        },
        {
          "symbol": "IL36G",
          "ensemblId": "ENSG00000136688",
          "biotype": "protein_coding",
          "start": 112973203,
          "end": 112985672,
          "strand": "+",
          "slug": "il36g"
        },
        {
          "symbol": "IL36A",
          "ensemblId": "ENSG00000136694",
          "biotype": "protein_coding",
          "start": 113005459,
          "end": 113008044,
          "strand": "+",
          "slug": "il36a"
        },
        {
          "symbol": "IL36B",
          "ensemblId": "ENSG00000136696",
          "biotype": "protein_coding",
          "start": 113022089,
          "end": 113052867,
          "strand": "-",
          "slug": "il36b"
        },
        {
          "symbol": "IL36RN",
          "ensemblId": "ENSG00000136695",
          "biotype": "protein_coding",
          "start": 113058638,
          "end": 113065382,
          "strand": "+",
          "slug": "il36rn"
        },
        {
          "symbol": "IL38",
          "ensemblId": "ENSG00000136697",
          "biotype": "protein_coding",
          "start": 113067970,
          "end": 113075843,
          "strand": "+",
          "slug": "il38"
        },
        {
          "symbol": "IL1RN",
          "ensemblId": "ENSG00000136689",
          "biotype": "protein_coding",
          "start": 113099315,
          "end": 113134016,
          "strand": "+",
          "slug": "il1rn"
        },
        {
          "symbol": "PSD4",
          "ensemblId": "ENSG00000125637",
          "biotype": "protein_coding",
          "start": 113157325,
          "end": 113209396,
          "strand": "+",
          "slug": "psd4"
        },
        {
          "symbol": "PAX8",
          "ensemblId": "ENSG00000125618",
          "biotype": "protein_coding",
          "start": 113215997,
          "end": 113279001,
          "strand": "-",
          "slug": "pax8"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "bloody-diarrhea",
        "name": "Bloody diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bloody-diarrhea"
      },
      {
        "slug": "elevated-circulating-c-reactive-protein-concentration",
        "name": "Elevated circulating C-reactive protein concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-circulating-c-reactive-protein-concentration"
      },
      {
        "slug": "increased-total-leukocyte-count",
        "name": "Elevated white blood count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-total-leukocyte-count"
      },
      {
        "slug": "elevated-erythrocyte-sedimentation-rate",
        "name": "High ESR",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-erythrocyte-sedimentation-rate"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "motor-delay",
        "name": "Motor delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/motor-delay"
      },
      {
        "slug": "ulcerative-colitis",
        "name": "Ulcerative colitis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/ulcerative-colitis"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}