{
  "url": "https://dantelabs.com/fr/genes/hoga1",
  "gene": {
    "slug": "hoga1",
    "symbol": "HOGA1",
    "name": "4-hydroxy-2-oxoglutarate aldolase 1",
    "hgnc": "HGNC:25155",
    "summary": null,
    "location": "10q24.2",
    "locusType": "gene with protein product",
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      "FLJ37472",
      "DHDPS2",
      "NPL2"
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      "DHDPSL"
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    "ensemblId": "ENSG00000241935",
    "entrezId": 112817,
    "omim": [
      "613597"
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    "uniprot": [
      "Q86XE5"
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      "release": "v1.5",
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      "strand": "+",
      "ensemblTranscript": "ENST00000370646.9",
      "refseqTranscript": "NM_138413.4",
      "ensemblProtein": "ENSP00000359680.4",
      "refseqProtein": "NP_612422.2",
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        },
        {
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      ],
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    },
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      "strand": "+"
    },
    "neighbourhood": {
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        {
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          "ensemblId": "ENSG00000187122",
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        {
          "symbol": "ARHGAP19-SLIT1",
          "ensemblId": "ENSG00000269891",
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        },
        {
          "symbol": "ARHGAP19",
          "ensemblId": "ENSG00000213390",
          "biotype": "protein_coding",
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        {
          "symbol": "FRAT1",
          "ensemblId": "ENSG00000165879",
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        {
          "symbol": "FRAT2",
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        {
          "symbol": "RRP12",
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        },
        {
          "symbol": "PGAM1",
          "ensemblId": "ENSG00000171314",
          "biotype": "protein_coding",
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          "strand": "+",
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        },
        {
          "symbol": "EXOSC1",
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        },
        {
          "symbol": "ZDHHC16",
          "ensemblId": "ENSG00000171307",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "zdhhc16"
        },
        {
          "symbol": "MMS19",
          "ensemblId": "ENSG00000155229",
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        },
        {
          "symbol": "UBTD1",
          "ensemblId": "ENSG00000165886",
          "biotype": "protein_coding",
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          "strand": "+",
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        },
        {
          "symbol": "ANKRD2",
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          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "ankrd2"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000249967",
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        },
        {
          "symbol": "C10orf62",
          "ensemblId": "ENSG00000203942",
          "biotype": "protein_coding",
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          "end": 97590934,
          "strand": "+",
          "slug": "c10orf62"
        },
        {
          "symbol": "MORN4",
          "ensemblId": "ENSG00000171160",
          "biotype": "protein_coding",
          "start": 97614551,
          "end": 97634137,
          "strand": "-",
          "slug": "morn4"
        },
        {
          "symbol": "PI4K2A",
          "ensemblId": "ENSG00000155252",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "AVPI1",
          "ensemblId": "ENSG00000119986",
          "biotype": "protein_coding",
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          "end": 97687561,
          "strand": "-",
          "slug": "avpi1"
        },
        {
          "symbol": "MARVELD1",
          "ensemblId": "ENSG00000155254",
          "biotype": "protein_coding",
          "start": 97713173,
          "end": 97718150,
          "strand": "+",
          "slug": "marveld1"
        },
        {
          "symbol": "ZFYVE27",
          "ensemblId": "ENSG00000155256",
          "biotype": "protein_coding",
          "start": 97737111,
          "end": 97760907,
          "strand": "+",
          "slug": "zfyve27"
        },
        {
          "symbol": "SFRP5",
          "ensemblId": "ENSG00000120057",
          "biotype": "protein_coding",
          "start": 97766751,
          "end": 97772287,
          "strand": "-",
          "slug": "sfrp5"
        },
        {
          "symbol": "GOLGA7B",
          "ensemblId": "ENSG00000155265",
          "biotype": "protein_coding",
          "start": 97821898,
          "end": 97871580,
          "strand": "+",
          "slug": "golga7b"
        },
        {
          "symbol": "CRTAC1",
          "ensemblId": "ENSG00000095713",
          "biotype": "protein_coding",
          "start": 97854711,
          "end": 98030828,
          "strand": "-",
          "slug": "crtac1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "primary-hyperoxaluria-238",
        "name": "Hyperoxalurie primitive",
        "diseases": [
          {
            "mondoId": "MONDO:0002474",
            "name": "Hyperoxalurie primitive",
            "genes": 3,
            "inheritance": "autosomal-recessive",
            "description": "Une maladie héréditaire caractérisée par une production excessive d'oxalate, entraînant une hyperoxalurie.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "Myriad Women's Health",
                "Natera",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/primary-hyperoxaluria-238"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-renal-physiology",
        "name": "Abnormal kidney function",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-renal-physiology"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "calcium-oxalate-nephrolithiasis",
        "name": "Calcium oxalate nephrolithiasis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/calcium-oxalate-nephrolithiasis"
      },
      {
        "slug": "pollakisuria",
        "name": "Constant urination",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pollakisuria"
      },
      {
        "slug": "dysuria",
        "name": "Dull burning sensation with urination",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/dysuria"
      },
      {
        "slug": "hyperoxaluria",
        "name": "High urine oxalate levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hyperoxaluria"
      },
      {
        "slug": "nephrocalcinosis",
        "name": "Increased calcium level in kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/nephrocalcinosis"
      },
      {
        "slug": "increased-urine-4-hydroxy-2-oxoglutarate-level",
        "name": "Increased urine 4-hydroxy-2-oxoglutarate level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/increased-urine-4-hydroxy-2-oxoglutarate-level"
      },
      {
        "slug": "pain",
        "name": "Pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pain"
      },
      {
        "slug": "abnormality-of-urine-homeostasis",
        "name": "Pee issues",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-urine-homeostasis"
      }
    ],
    "related": [
      {
        "slug": "agxt",
        "symbol": "AGXT",
        "name": "alanine--glyoxylate aminotransferase",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/agxt"
      },
      {
        "slug": "grhpr",
        "symbol": "GRHPR",
        "name": "glyoxylate and hydroxypyruvate reductase",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/grhpr"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}