{
  "url": "https://dantelabs.com/fr/genes/cpa1",
  "gene": {
    "slug": "cpa1",
    "symbol": "CPA1",
    "name": "carboxypeptidase A1",
    "hgnc": "HGNC:2296",
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    "location": "7q32.2",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "CPA"
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    "ensemblId": "ENSG00000091704",
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    "uniprot": [
      "P15085"
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      "release": "v1.5",
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      "strand": "+",
      "ensemblTranscript": "ENST00000011292.8",
      "refseqTranscript": "NM_001868.4",
      "ensemblProtein": "ENSP00000011292.3",
      "refseqProtein": "NP_001859.1",
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    },
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      "build": "GRCh37",
      "release": "87",
      "chrom": "7",
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      "end": 130027955,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
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      "genes": [
        {
          "symbol": "UBE2H",
          "ensemblId": "ENSG00000186591",
          "biotype": "protein_coding",
          "start": 129830732,
          "end": 129952988,
          "strand": "-",
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        },
        {
          "symbol": "ZC3HC1",
          "ensemblId": "ENSG00000091732",
          "biotype": "protein_coding",
          "start": 130018286,
          "end": 130051401,
          "strand": "-",
          "slug": "zc3hc1"
        },
        {
          "symbol": "KLHDC10",
          "ensemblId": "ENSG00000128607",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "TMEM209",
          "ensemblId": "ENSG00000146842",
          "biotype": "protein_coding",
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          "slug": "tmem209"
        },
        {
          "symbol": "SSMEM1",
          "ensemblId": "ENSG00000165120",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "ssmem1"
        },
        {
          "symbol": "CPA2",
          "ensemblId": "ENSG00000158516",
          "biotype": "protein_coding",
          "start": 130266821,
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          "strand": "+",
          "slug": "cpa2"
        },
        {
          "symbol": "CPA4",
          "ensemblId": "ENSG00000128510",
          "biotype": "protein_coding",
          "start": 130293118,
          "end": 130324180,
          "strand": "+",
          "slug": "cpa4"
        },
        {
          "symbol": "CPA5",
          "ensemblId": "ENSG00000158525",
          "biotype": "protein_coding",
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          "end": 130368730,
          "strand": "+",
          "slug": "cpa5"
        },
        {
          "symbol": "CEP41",
          "ensemblId": "ENSG00000106477",
          "biotype": "protein_coding",
          "start": 130393771,
          "end": 130442433,
          "strand": "-",
          "slug": "cep41"
        },
        {
          "symbol": "MEST",
          "ensemblId": "ENSG00000106484",
          "biotype": "protein_coding",
          "start": 130486171,
          "end": 130522765,
          "strand": "+",
          "slug": "mest"
        },
        {
          "symbol": "COPG2",
          "ensemblId": "ENSG00000158623",
          "biotype": "protein_coding",
          "start": 130505553,
          "end": 130668755,
          "strand": "-",
          "slug": "copg2"
        },
        {
          "symbol": "TSGA13",
          "ensemblId": "ENSG00000213265",
          "biotype": "protein_coding",
          "start": 130668643,
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          "strand": "-",
          "slug": "tsga13"
        },
        {
          "symbol": "KLF14",
          "ensemblId": "ENSG00000266265",
          "biotype": "protein_coding",
          "start": 130730697,
          "end": 130734207,
          "strand": "-",
          "slug": "klf14"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "pancreatitis",
        "name": "Pancréatite",
        "diseases": [
          {
            "mondoId": "MONDO:0004982",
            "name": "Pancréatite",
            "genes": 5,
            "inheritance": null,
            "description": "Inflammation du pancréas.",
            "management": "Prise en charge de la douleur ; traitement enzymatique substitutif en cas d'insuffisance pancréatique exocrine ; prise en charge du diabète ; surveillance annuelle par écho-endoscopie/MRCP pour le dépistage du cancer du pancréas dès l'âge de 40 ans ; pancréatectomie totale avec autogreffe d'îlots de Langerhans (TPIAT) dans les cas réfractaires",
            "evidence": {
              "gencc": [
                "Ambry Genetics"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fr/conditions/pancreatitis"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-circulating-enzyme-concentration-or-activity",
        "name": "Abnormal circulating enzyme concentration or activity",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-enzyme-concentration-or-activity"
      },
      {
        "slug": "diabetes-mellitus",
        "name": "Diabetes mellitus",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diabetes-mellitus"
      },
      {
        "slug": "elevated-circulating-c-reactive-protein-concentration",
        "name": "Elevated circulating C-reactive protein concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-c-reactive-protein-concentration"
      },
      {
        "slug": "increased-total-leukocyte-count",
        "name": "Elevated white blood count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-total-leukocyte-count"
      },
      {
        "slug": "jaundice",
        "name": "Jaundice",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/jaundice"
      },
      {
        "slug": "pancreatic-calcification",
        "name": "Pancreatic calcification",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pancreatic-calcification"
      },
      {
        "slug": "recurrent-pancreatitis",
        "name": "Recurring pancreas inflammation",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-pancreatitis"
      },
      {
        "slug": "splanchnic-vein-thrombosis",
        "name": "Splanchnic vein thrombosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/splanchnic-vein-thrombosis"
      }
    ],
    "related": [
      {
        "slug": "ctrc",
        "symbol": "CTRC",
        "name": "chymotrypsin C",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/ctrc"
      },
      {
        "slug": "prss1",
        "symbol": "PRSS1",
        "name": "serine protease 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/prss1"
      },
      {
        "slug": "spink1",
        "symbol": "SPINK1",
        "name": "serine peptidase inhibitor Kazal type 1",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/spink1"
      },
      {
        "slug": "trpv6",
        "symbol": "TRPV6",
        "name": "transient receptor potential cation channel subfamily V member 6",
        "shared": 1,
        "url": "https://dantelabs.com/fr/genes/trpv6"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}