{
  "url": "https://dantelabs.com/traits/tinnitus",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "tinnitus",
    "id": "HP:0000360",
    "name": "Ringing in ears",
    "label": "Tinnitus",
    "definition": "Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation.",
    "synonyms": [
      "Ringing in the ears"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-ear",
        "name": "Abnormality of the ear",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ear"
      }
    ],
    "broader": [
      {
        "slug": "hearing-abnormality",
        "name": "Hearing abnormality",
        "url": "https://dantelabs.com/traits/hearing-abnormality"
      }
    ],
    "narrower": [
      {
        "slug": "pulsatile-tinnitus",
        "name": "Pulsatile tinnitus",
        "genes": 17,
        "url": "https://dantelabs.com/traits/pulsatile-tinnitus"
      }
    ],
    "genes": [
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "ctsa",
        "symbol": "CTSA",
        "hgnc": "HGNC:9251",
        "name": "cathepsin A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsa"
      },
      {
        "slug": "thoc1",
        "symbol": "THOC1",
        "hgnc": "HGNC:19070",
        "name": "THO complex subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thoc1"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "hgnc": "HGNC:8768",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aifm1"
      },
      {
        "slug": "cacna1a",
        "symbol": "CACNA1A",
        "hgnc": "HGNC:1388",
        "name": "calcium voltage-gated channel subunit alpha1 A",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/cacna1a"
      },
      {
        "slug": "cav1",
        "symbol": "CAV1",
        "hgnc": "HGNC:1527",
        "name": "caveolin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cav1"
      },
      {
        "slug": "ccnd1",
        "symbol": "CCND1",
        "hgnc": "HGNC:1582",
        "name": "cyclin D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnd1"
      },
      {
        "slug": "diablo",
        "symbol": "DIABLO",
        "hgnc": "HGNC:21528",
        "name": "diablo IAP-binding mitochondrial protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/diablo"
      },
      {
        "slug": "dkk1",
        "symbol": "DKK1",
        "hgnc": "HGNC:2891",
        "name": "dickkopf Wnt signaling pathway inhibitor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dkk1"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "gla",
        "symbol": "GLA",
        "hgnc": "HGNC:4296",
        "name": "galactosidase alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gla"
      },
      {
        "slug": "grm1",
        "symbol": "GRM1",
        "hgnc": "HGNC:4593",
        "name": "glutamate metabotropic receptor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grm1"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "myo3a",
        "symbol": "MYO3A",
        "hgnc": "HGNC:7601",
        "name": "myosin IIIA",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myo3a"
      },
      {
        "slug": "naga",
        "symbol": "NAGA",
        "hgnc": "HGNC:7631",
        "name": "alpha-N-acetylgalactosaminidase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naga"
      },
      {
        "slug": "ptpn22",
        "symbol": "PTPN22",
        "hgnc": "HGNC:9652",
        "name": "protein tyrosine phosphatase non-receptor type 22",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn22"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sdhb",
        "symbol": "SDHB",
        "hgnc": "HGNC:10681",
        "name": "succinate dehydrogenase complex iron sulfur subunit B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhb"
      },
      {
        "slug": "sdhc",
        "symbol": "SDHC",
        "hgnc": "HGNC:10682",
        "name": "succinate dehydrogenase complex subunit C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhc"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "vhl",
        "symbol": "VHL",
        "hgnc": "HGNC:12687",
        "name": "von Hippel-Lindau tumor suppressor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vhl"
      },
      {
        "slug": "atp1a2",
        "symbol": "ATP1A2",
        "hgnc": "HGNC:800",
        "name": "ATPase Na+/K+ transporting subunit alpha 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp1a2"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "hgnc": "HGNC:815",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2b2"
      },
      {
        "slug": "cacna1d",
        "symbol": "CACNA1D",
        "hgnc": "HGNC:1391",
        "name": "calcium voltage-gated channel subunit alpha1 D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1d"
      },
      {
        "slug": "clcn2",
        "symbol": "CLCN2",
        "hgnc": "HGNC:2020",
        "name": "chloride voltage-gated channel 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn2"
      },
      {
        "slug": "coq6",
        "symbol": "COQ6",
        "hgnc": "HGNC:20233",
        "name": "coenzyme Q6, monooxygenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq6"
      },
      {
        "slug": "cyp11b1",
        "symbol": "CYP11B1",
        "hgnc": "HGNC:2591",
        "name": "cytochrome P450 family 11 subfamily B member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp11b1"
      },
      {
        "slug": "cyp11b2",
        "symbol": "CYP11B2",
        "hgnc": "HGNC:2592",
        "name": "cytochrome P450 family 11 subfamily B member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp11b2"
      },
      {
        "slug": "kcnj5",
        "symbol": "KCNJ5",
        "hgnc": "HGNC:6266",
        "name": "potassium inwardly rectifying channel subfamily J member 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj5"
      },
      {
        "slug": "lztr1",
        "symbol": "LZTR1",
        "hgnc": "HGNC:6742",
        "name": "leucine zipper like post translational regulator 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lztr1"
      },
      {
        "slug": "mir96",
        "symbol": "MIR96",
        "hgnc": "HGNC:31648",
        "name": "microRNA 96",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mir96"
      },
      {
        "slug": "nf2",
        "symbol": "NF2",
        "hgnc": "HGNC:7773",
        "name": "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/nf2"
      },
      {
        "slug": "phex",
        "symbol": "PHEX",
        "hgnc": "HGNC:8918",
        "name": "phosphate regulating endopeptidase X-linked",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phex"
      },
      {
        "slug": "pmp22",
        "symbol": "PMP22",
        "hgnc": "HGNC:9118",
        "name": "peripheral myelin protein 22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmp22"
      },
      {
        "slug": "prrt2",
        "symbol": "PRRT2",
        "hgnc": "HGNC:30500",
        "name": "proline rich transmembrane protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prrt2"
      },
      {
        "slug": "rrp12",
        "symbol": "RRP12",
        "hgnc": "HGNC:29100",
        "name": "ribosomal RNA processing 12 homolog",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrp12"
      },
      {
        "slug": "scn1a",
        "symbol": "SCN1A",
        "hgnc": "HGNC:10585",
        "name": "sodium voltage-gated channel alpha subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1a"
      },
      {
        "slug": "smarcb1",
        "symbol": "SMARCB1",
        "hgnc": "HGNC:11103",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit B1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smarcb1"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "bap1",
        "symbol": "BAP1",
        "hgnc": "HGNC:950",
        "name": "BRCA1 associated deubiquitinase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bap1"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "pdgfb",
        "symbol": "PDGFB",
        "hgnc": "HGNC:8800",
        "name": "platelet derived growth factor subunit B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfb"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "smarce1",
        "symbol": "SMARCE1",
        "hgnc": "HGNC:11109",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit E1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarce1"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smo"
      },
      {
        "slug": "sufu",
        "symbol": "SUFU",
        "hgnc": "HGNC:16466",
        "name": "SUFU negative regulator of hedgehog signaling",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sufu"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "traf7",
        "symbol": "TRAF7",
        "hgnc": "HGNC:20456",
        "name": "TNF receptor associated factor 7",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf7"
      },
      {
        "slug": "coch",
        "symbol": "COCH",
        "hgnc": "HGNC:2180",
        "name": "cochlin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coch"
      },
      {
        "slug": "dspp",
        "symbol": "DSPP",
        "hgnc": "HGNC:3054",
        "name": "dentin sialophosphoprotein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dspp"
      },
      {
        "slug": "kcnq4",
        "symbol": "KCNQ4",
        "hgnc": "HGNC:6298",
        "name": "potassium voltage-gated channel subfamily Q member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq4"
      },
      {
        "slug": "mfn2",
        "symbol": "MFN2",
        "hgnc": "HGNC:16877",
        "name": "mitofusin 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mfn2"
      },
      {
        "slug": "osbpl2",
        "symbol": "OSBPL2",
        "hgnc": "HGNC:15761",
        "name": "oxysterol binding protein like 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/osbpl2"
      },
      {
        "slug": "p2rx2",
        "symbol": "P2RX2",
        "hgnc": "HGNC:15459",
        "name": "purinergic receptor P2X 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/p2rx2"
      },
      {
        "slug": "slc39a14",
        "symbol": "SLC39A14",
        "hgnc": "HGNC:20858",
        "name": "solute carrier family 39 member 14",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc39a14"
      },
      {
        "slug": "slc44a4",
        "symbol": "SLC44A4",
        "hgnc": "HGNC:13941",
        "name": "solute carrier family 44 member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc44a4"
      },
      {
        "slug": "tmc1",
        "symbol": "TMC1",
        "hgnc": "HGNC:16513",
        "name": "transmembrane channel like 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmc1"
      }
    ]
  }
}