{
  "url": "https://dantelabs.com/traits/sirenomelia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "sirenomelia",
    "id": "HP:0010497",
    "name": "Sirenomelia",
    "definition": "A developmental defect in which the legs are fused together.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-lower-limb",
        "name": "Abnormality of the lower limb",
        "url": "https://dantelabs.com/traits/abnormality-of-the-lower-limb"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "dact1",
        "symbol": "DACT1",
        "hgnc": "HGNC:17748",
        "name": "dishevelled binding antagonist of beta catenin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dact1"
      },
      {
        "slug": "fgf20",
        "symbol": "FGF20",
        "hgnc": "HGNC:3677",
        "name": "fibroblast growth factor 20",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf20"
      },
      {
        "slug": "gfra1",
        "symbol": "GFRA1",
        "hgnc": "HGNC:4243",
        "name": "GDNF family receptor alpha 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfra1"
      },
      {
        "slug": "greb1l",
        "symbol": "GREB1L",
        "hgnc": "HGNC:31042",
        "name": "GREB1 like retinoic acid receptor coactivator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/greb1l"
      },
      {
        "slug": "itga8",
        "symbol": "ITGA8",
        "hgnc": "HGNC:6144",
        "name": "integrin subunit alpha 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga8"
      },
      {
        "slug": "ret",
        "symbol": "RET",
        "hgnc": "HGNC:9967",
        "name": "ret proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ret"
      },
      {
        "slug": "wnt9b",
        "symbol": "WNT9B",
        "hgnc": "HGNC:12779",
        "name": "Wnt family member 9B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt9b"
      },
      {
        "slug": "atp6v1b2",
        "symbol": "ATP6V1B2",
        "hgnc": "HGNC:854",
        "name": "ATPase H+ transporting V1 subunit B2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b2"
      },
      {
        "slug": "tbc1d24",
        "symbol": "TBC1D24",
        "hgnc": "HGNC:29203",
        "name": "TBC1 domain family member 24",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d24"
      }
    ]
  }
}