{
  "url": "https://dantelabs.com/traits/recurrent-pneumonia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "recurrent-pneumonia",
    "id": "HP:0006532",
    "name": "Recurrent pneumonia",
    "definition": "An increased susceptibility to pneumonia as manifested by a history of recurrent episodes of pneumonia.",
    "synonyms": [
      "Multiple pulmonary infections",
      "Pneumonia, recurrent",
      "Pneumonia, recurrent episodes",
      "Pulmonary infection",
      "Pulmonary infections",
      "pulmonary infections, recurrent",
      "Recurrent pulmonary infections"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "pneumonia",
        "name": "Pneumonia",
        "url": "https://dantelabs.com/traits/pneumonia"
      },
      {
        "slug": "recurrent-lower-respiratory-tract-infections",
        "name": "Recurrent chest infections",
        "url": "https://dantelabs.com/traits/recurrent-lower-respiratory-tract-infections"
      }
    ],
    "narrower": [
      {
        "slug": "recurrent-viral-pneumonia",
        "name": "Recurrent viral pneumonia",
        "genes": 1,
        "url": "https://dantelabs.com/traits/recurrent-viral-pneumonia"
      }
    ],
    "genes": [
      {
        "slug": "ada",
        "symbol": "ADA",
        "hgnc": "HGNC:186",
        "name": "adenosine deaminase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ada"
      },
      {
        "slug": "alg12",
        "symbol": "ALG12",
        "hgnc": "HGNC:19358",
        "name": "ALG12 alpha-1,6-mannosyltransferase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alg12"
      },
      {
        "slug": "b3galt6",
        "symbol": "B3GALT6",
        "hgnc": "HGNC:17978",
        "name": "beta-1,3-galactosyltransferase 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b3galt6"
      },
      {
        "slug": "blnk",
        "symbol": "BLNK",
        "hgnc": "HGNC:14211",
        "name": "B cell linker",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blnk"
      },
      {
        "slug": "c3",
        "symbol": "C3",
        "hgnc": "HGNC:1318",
        "name": "complement C3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c3"
      },
      {
        "slug": "cd247",
        "symbol": "CD247",
        "hgnc": "HGNC:1677",
        "name": "CD247 molecule",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cd247"
      },
      {
        "slug": "cd3e",
        "symbol": "CD3E",
        "hgnc": "HGNC:1674",
        "name": "CD3 epsilon subunit of T-cell receptor complex",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cd3e"
      },
      {
        "slug": "cd79b",
        "symbol": "CD79B",
        "hgnc": "HGNC:1699",
        "name": "CD79b molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd79b"
      },
      {
        "slug": "cebpe",
        "symbol": "CEBPE",
        "hgnc": "HGNC:1836",
        "name": "CCAAT enhancer binding protein epsilon",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cebpe"
      },
      {
        "slug": "copz1",
        "symbol": "COPZ1",
        "hgnc": "HGNC:2243",
        "name": "coat protein complex I subunit zeta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/copz1"
      },
      {
        "slug": "cybb",
        "symbol": "CYBB",
        "hgnc": "HGNC:2578",
        "name": "cytochrome b-245 beta chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybb"
      },
      {
        "slug": "cybc1",
        "symbol": "CYBC1",
        "hgnc": "HGNC:28672",
        "name": "cytochrome b-245 chaperone 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybc1"
      },
      {
        "slug": "dot1l",
        "symbol": "DOT1L",
        "hgnc": "HGNC:24948",
        "name": "DOT1 like histone lysine methyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dot1l"
      },
      {
        "slug": "drc1",
        "symbol": "DRC1",
        "hgnc": "HGNC:24245",
        "name": "dynein regulatory complex subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc1"
      },
      {
        "slug": "ercc6",
        "symbol": "ERCC6",
        "hgnc": "HGNC:3438",
        "name": "ERCC excision repair 6, chromatin remodeling factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc6"
      },
      {
        "slug": "fcho1",
        "symbol": "FCHO1",
        "hgnc": "HGNC:29002",
        "name": "FCH and mu domain containing endocytic adaptor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcho1"
      },
      {
        "slug": "flt3lg",
        "symbol": "FLT3LG",
        "hgnc": "HGNC:3766",
        "name": "fms related receptor tyrosine kinase 3 ligand",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flt3lg"
      },
      {
        "slug": "galns",
        "symbol": "GALNS",
        "hgnc": "HGNC:4122",
        "name": "galactosamine (N-acetyl)-6-sulfatase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galns"
      },
      {
        "slug": "igbp1",
        "symbol": "IGBP1",
        "hgnc": "HGNC:5461",
        "name": "immunoglobulin binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igbp1"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikbkg"
      },
      {
        "slug": "ikzf2",
        "symbol": "IKZF2",
        "hgnc": "HGNC:13177",
        "name": "IKAROS family zinc finger 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ikzf2"
      },
      {
        "slug": "il21r",
        "symbol": "IL21R",
        "hgnc": "HGNC:6006",
        "name": "interleukin 21 receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il21r"
      },
      {
        "slug": "il6st",
        "symbol": "IL6ST",
        "hgnc": "HGNC:6021",
        "name": "interleukin 6 cytokine family signal transducer",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/il6st"
      },
      {
        "slug": "inpp4a",
        "symbol": "INPP4A",
        "hgnc": "HGNC:6074",
        "name": "inositol polyphosphate-4-phosphatase type I A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp4a"
      },
      {
        "slug": "irf4",
        "symbol": "IRF4",
        "hgnc": "HGNC:6119",
        "name": "interferon regulatory factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf4"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "lat",
        "symbol": "LAT",
        "hgnc": "HGNC:18874",
        "name": "linker for activation of T cells",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lat"
      },
      {
        "slug": "man2b2",
        "symbol": "MAN2B2",
        "hgnc": "HGNC:29623",
        "name": "mannosidase alpha class 2B member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man2b2"
      },
      {
        "slug": "masp2",
        "symbol": "MASP2",
        "hgnc": "HGNC:6902",
        "name": "MBL associated serine protease 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/masp2"
      },
      {
        "slug": "megf10",
        "symbol": "MEGF10",
        "hgnc": "HGNC:29634",
        "name": "multiple EGF like domains 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/megf10"
      },
      {
        "slug": "mocs3",
        "symbol": "MOCS3",
        "hgnc": "HGNC:15765",
        "name": "molybdenum cofactor synthesis 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mocs3"
      },
      {
        "slug": "mrap",
        "symbol": "MRAP",
        "hgnc": "HGNC:1304",
        "name": "melanocortin 2 receptor accessory protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrap"
      },
      {
        "slug": "nhej1",
        "symbol": "NHEJ1",
        "hgnc": "HGNC:25737",
        "name": "non-homologous end joining factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nhej1"
      },
      {
        "slug": "nme5",
        "symbol": "NME5",
        "hgnc": "HGNC:7853",
        "name": "NME/NM23 family member 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nme5"
      },
      {
        "slug": "odad4",
        "symbol": "ODAD4",
        "hgnc": "HGNC:25280",
        "name": "outer dynein arm docking complex subunit 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad4"
      },
      {
        "slug": "pik3cd",
        "symbol": "PIK3CD",
        "hgnc": "HGNC:8977",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cd"
      },
      {
        "slug": "pld4",
        "symbol": "PLD4",
        "hgnc": "HGNC:23792",
        "name": "phospholipase D family member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pld4"
      },
      {
        "slug": "pola1",
        "symbol": "POLA1",
        "hgnc": "HGNC:9173",
        "name": "DNA polymerase alpha 1, catalytic subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pola1"
      },
      {
        "slug": "ptcra",
        "symbol": "PTCRA",
        "hgnc": "HGNC:21290",
        "name": "pre T cell antigen receptor alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptcra"
      },
      {
        "slug": "relb",
        "symbol": "RELB",
        "hgnc": "HGNC:9956",
        "name": "RELB proto-oncogene, NF-kB subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/relb"
      },
      {
        "slug": "rfxap",
        "symbol": "RFXAP",
        "hgnc": "HGNC:9988",
        "name": "regulatory factor X associated protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfxap"
      },
      {
        "slug": "rnu6atac",
        "symbol": "RNU6ATAC",
        "hgnc": "HGNC:34017",
        "name": "RNA, U6atac small nuclear",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu6atac"
      },
      {
        "slug": "serpinh1",
        "symbol": "SERPINH1",
        "hgnc": "HGNC:1546",
        "name": "serpin family H member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpinh1"
      },
      {
        "slug": "sftpc",
        "symbol": "SFTPC",
        "hgnc": "HGNC:10802",
        "name": "surfactant protein C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sftpc"
      },
      {
        "slug": "smarcd2",
        "symbol": "SMARCD2",
        "hgnc": "HGNC:11107",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit D2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcd2"
      },
      {
        "slug": "stk36",
        "symbol": "STK36",
        "hgnc": "HGNC:17209",
        "name": "serine/threonine kinase 36",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk36"
      },
      {
        "slug": "tm2d3",
        "symbol": "TM2D3",
        "hgnc": "HGNC:24128",
        "name": "TM2 domain containing 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tm2d3"
      },
      {
        "slug": "tnfrsf13c",
        "symbol": "TNFRSF13C",
        "hgnc": "HGNC:17755",
        "name": "TNF receptor superfamily member 13C",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tnfrsf13c"
      },
      {
        "slug": "unc119",
        "symbol": "UNC119",
        "hgnc": "HGNC:12565",
        "name": "unc-119 lipid binding chaperone",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc119"
      },
      {
        "slug": "vps33a",
        "symbol": "VPS33A",
        "hgnc": "HGNC:18179",
        "name": "VPS33A core subunit of CORVET and HOPS complexes",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps33a"
      },
      {
        "slug": "btk",
        "symbol": "BTK",
        "hgnc": "HGNC:1133",
        "name": "Bruton tyrosine kinase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/btk"
      },
      {
        "slug": "dnah11",
        "symbol": "DNAH11",
        "hgnc": "HGNC:2942",
        "name": "dynein axonemal heavy chain 11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah11"
      },
      {
        "slug": "nbn",
        "symbol": "NBN",
        "hgnc": "HGNC:7652",
        "name": "nibrin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nbn"
      },
      {
        "slug": "nfkb2",
        "symbol": "NFKB2",
        "hgnc": "HGNC:7795",
        "name": "nuclear factor kappa B subunit 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nfkb2"
      },
      {
        "slug": "rfx5",
        "symbol": "RFX5",
        "hgnc": "HGNC:9986",
        "name": "regulatory factor X5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx5"
      },
      {
        "slug": "rfxank",
        "symbol": "RFXANK",
        "hgnc": "HGNC:9987",
        "name": "regulatory factor X associated ankyrin containing protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfxank"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "ap3b1",
        "symbol": "AP3B1",
        "hgnc": "HGNC:566",
        "name": "adaptor related protein complex 3 subunit beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap3b1"
      },
      {
        "slug": "arpc1b",
        "symbol": "ARPC1B",
        "hgnc": "HGNC:704",
        "name": "actin related protein 2/3 complex subunit 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arpc1b"
      },
      {
        "slug": "carmil2",
        "symbol": "CARMIL2",
        "hgnc": "HGNC:27089",
        "name": "capping protein regulator and myosin 1 linker 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/carmil2"
      },
      {
        "slug": "cavin1",
        "symbol": "CAVIN1",
        "hgnc": "HGNC:9688",
        "name": "caveolae associated protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cavin1"
      },
      {
        "slug": "ccdc39",
        "symbol": "CCDC39",
        "hgnc": "HGNC:25244",
        "name": "coiled-coil domain 39 molecular ruler complex subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc39"
      },
      {
        "slug": "ccdc40",
        "symbol": "CCDC40",
        "hgnc": "HGNC:26090",
        "name": "coiled-coil domain 40 molecular ruler complex subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc40"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "clxn",
        "symbol": "CLXN",
        "hgnc": "HGNC:25678",
        "name": "calaxin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clxn"
      },
      {
        "slug": "cxcr4",
        "symbol": "CXCR4",
        "hgnc": "HGNC:2561",
        "name": "C-X-C motif chemokine receptor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cxcr4"
      },
      {
        "slug": "dock2",
        "symbol": "DOCK2",
        "hgnc": "HGNC:2988",
        "name": "dedicator of cytokinesis 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock2"
      },
      {
        "slug": "dock8",
        "symbol": "DOCK8",
        "hgnc": "HGNC:19191",
        "name": "dedicator of cytokinesis 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock8"
      },
      {
        "slug": "extl3",
        "symbol": "EXTL3",
        "hgnc": "HGNC:3518",
        "name": "exostosin like glycosyltransferase 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/extl3"
      },
      {
        "slug": "fcgr2a",
        "symbol": "FCGR2A",
        "hgnc": "HGNC:3616",
        "name": "Fc gamma receptor IIa",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr2a"
      },
      {
        "slug": "ighm",
        "symbol": "IGHM",
        "hgnc": "HGNC:5541",
        "name": "immunoglobulin heavy constant mu",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighm"
      },
      {
        "slug": "il2rg",
        "symbol": "IL2RG",
        "hgnc": "HGNC:6010",
        "name": "interleukin 2 receptor subunit gamma",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2rg"
      },
      {
        "slug": "kcnj6",
        "symbol": "KCNJ6",
        "hgnc": "HGNC:6267",
        "name": "potassium inwardly rectifying channel subfamily J member 6",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj6"
      },
      {
        "slug": "lmnb1",
        "symbol": "LMNB1",
        "hgnc": "HGNC:6637",
        "name": "lamin B1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmnb1"
      },
      {
        "slug": "med25",
        "symbol": "MED25",
        "hgnc": "HGNC:28845",
        "name": "mediator complex subunit 25",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/med25"
      },
      {
        "slug": "nfkb1",
        "symbol": "NFKB1",
        "hgnc": "HGNC:7794",
        "name": "nuclear factor kappa B subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfkb1"
      },
      {
        "slug": "odad1",
        "symbol": "ODAD1",
        "hgnc": "HGNC:26560",
        "name": "outer dynein arm docking complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad1"
      },
      {
        "slug": "odad2",
        "symbol": "ODAD2",
        "hgnc": "HGNC:25583",
        "name": "outer dynein arm docking complex subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad2"
      },
      {
        "slug": "pgm3",
        "symbol": "PGM3",
        "hgnc": "HGNC:8907",
        "name": "phosphoglucomutase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgm3"
      },
      {
        "slug": "rac2",
        "symbol": "RAC2",
        "hgnc": "HGNC:9802",
        "name": "Rac family small GTPase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rac2"
      },
      {
        "slug": "rnf168",
        "symbol": "RNF168",
        "hgnc": "HGNC:26661",
        "name": "ring finger protein 168",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf168"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "hgnc": "HGNC:10193",
        "name": "RNA, U4 small nuclear 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4-2"
      },
      {
        "slug": "rnu4atac",
        "symbol": "RNU4ATAC",
        "hgnc": "HGNC:34016",
        "name": "RNA, U4atac small nuclear",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rnu4atac"
      },
      {
        "slug": "siah1",
        "symbol": "SIAH1",
        "hgnc": "HGNC:10857",
        "name": "siah E3 ubiquitin protein ligase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/siah1"
      },
      {
        "slug": "smpd1",
        "symbol": "SMPD1",
        "hgnc": "HGNC:11120",
        "name": "sphingomyelin phosphodiesterase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smpd1"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "stim1",
        "symbol": "STIM1",
        "hgnc": "HGNC:11386",
        "name": "stromal interaction molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stim1"
      },
      {
        "slug": "stk4",
        "symbol": "STK4",
        "hgnc": "HGNC:11408",
        "name": "serine/threonine kinase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk4"
      },
      {
        "slug": "tbx1",
        "symbol": "TBX1",
        "hgnc": "HGNC:11592",
        "name": "T-box transcription factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx1"
      },
      {
        "slug": "tcf3",
        "symbol": "TCF3",
        "hgnc": "HGNC:11633",
        "name": "transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf3"
      },
      {
        "slug": "tgfb1",
        "symbol": "TGFB1",
        "hgnc": "HGNC:11766",
        "name": "transforming growth factor beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfb1"
      },
      {
        "slug": "usb1",
        "symbol": "USB1",
        "hgnc": "HGNC:25792",
        "name": "U6 snRNA biogenesis phosphodiesterase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usb1"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "wdr1",
        "symbol": "WDR1",
        "hgnc": "HGNC:12754",
        "name": "WD repeat domain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr1"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "wdr35",
        "symbol": "WDR35",
        "hgnc": "HGNC:29250",
        "name": "WD repeat domain 35",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr35"
      },
      {
        "slug": "aass",
        "symbol": "AASS",
        "hgnc": "HGNC:17366",
        "name": "aminoadipate-semialdehyde synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aass"
      },
      {
        "slug": "cd27",
        "symbol": "CD27",
        "hgnc": "HGNC:11922",
        "name": "CD27 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd27"
      },
      {
        "slug": "cd3d",
        "symbol": "CD3D",
        "hgnc": "HGNC:1673",
        "name": "CD3 delta subunit of T-cell receptor complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd3d"
      },
      {
        "slug": "cfap410",
        "symbol": "CFAP410",
        "hgnc": "HGNC:1260",
        "name": "cilia and flagella associated protein 410",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap410"
      },
      {
        "slug": "clpb",
        "symbol": "CLPB",
        "hgnc": "HGNC:30664",
        "name": "ClpB family mitochondrial disaggregase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clpb"
      },
      {
        "slug": "dnaaf4",
        "symbol": "DNAAF4",
        "hgnc": "HGNC:21493",
        "name": "dynein axonemal assembly factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf4"
      },
      {
        "slug": "dock11",
        "symbol": "DOCK11",
        "hgnc": "HGNC:23483",
        "name": "dedicator of cytokinesis 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock11"
      },
      {
        "slug": "dst",
        "symbol": "DST",
        "hgnc": "HGNC:1090",
        "name": "dystonin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dst"
      },
      {
        "slug": "dzip1l",
        "symbol": "DZIP1L",
        "hgnc": "HGNC:26551",
        "name": "DAZ interacting zinc finger protein 1 like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dzip1l"
      },
      {
        "slug": "efemp2",
        "symbol": "EFEMP2",
        "hgnc": "HGNC:3219",
        "name": "EGF-like fibulin extracellular matrix protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efemp2"
      },
      {
        "slug": "elfn1",
        "symbol": "ELFN1",
        "hgnc": "HGNC:33154",
        "name": "extracellular leucine rich repeat and fibronectin type III domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elfn1"
      },
      {
        "slug": "fbln5",
        "symbol": "FBLN5",
        "hgnc": "HGNC:3602",
        "name": "fibulin 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbln5"
      },
      {
        "slug": "fbxw7",
        "symbol": "FBXW7",
        "hgnc": "HGNC:16712",
        "name": "F-box and WD repeat domain containing 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxw7"
      },
      {
        "slug": "idh1",
        "symbol": "IDH1",
        "hgnc": "HGNC:5382",
        "name": "isocitrate dehydrogenase (NADP(+)) 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idh1"
      },
      {
        "slug": "ighg2",
        "symbol": "IGHG2",
        "hgnc": "HGNC:5526",
        "name": "immunoglobulin heavy constant gamma 2 (G2m marker)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighg2"
      },
      {
        "slug": "igkc",
        "symbol": "IGKC",
        "hgnc": "HGNC:5716",
        "name": "immunoglobulin kappa constant",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igkc"
      },
      {
        "slug": "jak3",
        "symbol": "JAK3",
        "hgnc": "HGNC:6193",
        "name": "Janus kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak3"
      },
      {
        "slug": "kptn",
        "symbol": "KPTN",
        "hgnc": "HGNC:6404",
        "name": "kaptin, actin binding protein",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kptn"
      },
      {
        "slug": "lrba",
        "symbol": "LRBA",
        "hgnc": "HGNC:1742",
        "name": "LPS responsive beige-like anchor protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrba"
      },
      {
        "slug": "ltbp1",
        "symbol": "LTBP1",
        "hgnc": "HGNC:6714",
        "name": "latent transforming growth factor beta binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ltbp1"
      },
      {
        "slug": "ltbp4",
        "symbol": "LTBP4",
        "hgnc": "HGNC:6717",
        "name": "latent transforming growth factor beta binding protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ltbp4"
      },
      {
        "slug": "ndc1",
        "symbol": "NDC1",
        "hgnc": "HGNC:25525",
        "name": "NDC1 transmembrane nucleoporin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndc1"
      },
      {
        "slug": "nkx2-1",
        "symbol": "NKX2-1",
        "hgnc": "HGNC:11825",
        "name": "NK2 homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-1"
      },
      {
        "slug": "pkhd1",
        "symbol": "PKHD1",
        "hgnc": "HGNC:9016",
        "name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkhd1"
      },
      {
        "slug": "pkp1",
        "symbol": "PKP1",
        "hgnc": "HGNC:9023",
        "name": "plakophilin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkp1"
      },
      {
        "slug": "pura",
        "symbol": "PURA",
        "hgnc": "HGNC:9701",
        "name": "purine rich element binding protein A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pura"
      },
      {
        "slug": "rac1",
        "symbol": "RAC1",
        "hgnc": "HGNC:9801",
        "name": "Rac family small GTPase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rac1"
      },
      {
        "slug": "rfx7",
        "symbol": "RFX7",
        "hgnc": "HGNC:25777",
        "name": "regulatory factor X7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx7"
      },
      {
        "slug": "rnf125",
        "symbol": "RNF125",
        "hgnc": "HGNC:21150",
        "name": "ring finger protein 125",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf125"
      },
      {
        "slug": "slc35c1",
        "symbol": "SLC35C1",
        "hgnc": "HGNC:20197",
        "name": "solute carrier family 35 member C1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35c1"
      },
      {
        "slug": "smarca2",
        "symbol": "SMARCA2",
        "hgnc": "HGNC:11098",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarca2"
      },
      {
        "slug": "srebf1",
        "symbol": "SREBF1",
        "hgnc": "HGNC:11289",
        "name": "sterol regulatory element binding transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srebf1"
      },
      {
        "slug": "stat5b",
        "symbol": "STAT5B",
        "hgnc": "HGNC:11367",
        "name": "signal transducer and activator of transcription 5B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat5b"
      },
      {
        "slug": "tonsl",
        "symbol": "TONSL",
        "hgnc": "HGNC:7801",
        "name": "tonsoku like, DNA repair protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tonsl"
      },
      {
        "slug": "zbtb7a",
        "symbol": "ZBTB7A",
        "hgnc": "HGNC:18078",
        "name": "zinc finger and BTB domain containing 7A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb7a"
      },
      {
        "slug": "znf341",
        "symbol": "ZNF341",
        "hgnc": "HGNC:15992",
        "name": "zinc finger protein 341",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf341"
      },
      {
        "slug": "znfx1",
        "symbol": "ZNFX1",
        "hgnc": "HGNC:29271",
        "name": "zinc finger NFX1-type containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znfx1"
      },
      {
        "slug": "ids",
        "symbol": "IDS",
        "hgnc": "HGNC:5389",
        "name": "iduronate 2-sulfatase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ids"
      },
      {
        "slug": "plod1",
        "symbol": "PLOD1",
        "hgnc": "HGNC:9081",
        "name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/plod1"
      },
      {
        "slug": "setbp1",
        "symbol": "SETBP1",
        "hgnc": "HGNC:15573",
        "name": "SET binding protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setbp1"
      },
      {
        "slug": "tbcd",
        "symbol": "TBCD",
        "hgnc": "HGNC:11581",
        "name": "tubulin folding cofactor D",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbcd"
      },
      {
        "slug": "cd19",
        "symbol": "CD19",
        "hgnc": "HGNC:1633",
        "name": "CD19 molecule",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd19"
      },
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "hgnc": "HGNC:2187",
        "name": "collagen type XI alpha 2 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col11a2"
      },
      {
        "slug": "cr2",
        "symbol": "CR2",
        "hgnc": "HGNC:2336",
        "name": "complement C3d receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cr2"
      },
      {
        "slug": "cyba",
        "symbol": "CYBA",
        "hgnc": "HGNC:2577",
        "name": "cytochrome b-245 alpha chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyba"
      },
      {
        "slug": "ddr2",
        "symbol": "DDR2",
        "hgnc": "HGNC:2731",
        "name": "discoidin domain receptor tyrosine kinase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddr2"
      },
      {
        "slug": "drc4",
        "symbol": "DRC4",
        "hgnc": "HGNC:4166",
        "name": "dynein regulatory complex subunit 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc4"
      },
      {
        "slug": "egfr",
        "symbol": "EGFR",
        "hgnc": "HGNC:3236",
        "name": "epidermal growth factor receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/egfr"
      },
      {
        "slug": "fmo3",
        "symbol": "FMO3",
        "hgnc": "HGNC:3771",
        "name": "flavin containing dimethylaniline monoxygenase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fmo3"
      },
      {
        "slug": "foxn1",
        "symbol": "FOXN1",
        "hgnc": "HGNC:12765",
        "name": "forkhead box N1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxn1"
      },
      {
        "slug": "gnptab",
        "symbol": "GNPTAB",
        "hgnc": "HGNC:29670",
        "name": "N-acetylglucosamine-1-phosphate transferase subunits alpha and beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnptab"
      },
      {
        "slug": "hydin",
        "symbol": "HYDIN",
        "hgnc": "HGNC:19368",
        "name": "HYDIN axonemal central pair apparatus protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hydin"
      },
      {
        "slug": "icos",
        "symbol": "ICOS",
        "hgnc": "HGNC:5351",
        "name": "inducible T cell costimulator",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/icos"
      },
      {
        "slug": "igll1",
        "symbol": "IGLL1",
        "hgnc": "HGNC:5870",
        "name": "immunoglobulin lambda like polypeptide 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igll1"
      },
      {
        "slug": "lep",
        "symbol": "LEP",
        "hgnc": "HGNC:6553",
        "name": "leptin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lep"
      },
      {
        "slug": "mthfd1",
        "symbol": "MTHFD1",
        "hgnc": "HGNC:7432",
        "name": "methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfd1"
      },
      {
        "slug": "ncf1",
        "symbol": "NCF1",
        "hgnc": "HGNC:7660",
        "name": "neutrophil cytosolic factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf1"
      },
      {
        "slug": "ncf2",
        "symbol": "NCF2",
        "hgnc": "HGNC:7661",
        "name": "neutrophil cytosolic factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf2"
      },
      {
        "slug": "orc6",
        "symbol": "ORC6",
        "hgnc": "HGNC:17151",
        "name": "origin recognition complex subunit 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/orc6"
      },
      {
        "slug": "pepd",
        "symbol": "PEPD",
        "hgnc": "HGNC:8840",
        "name": "peptidase D",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pepd"
      },
      {
        "slug": "tnfrsf11a",
        "symbol": "TNFRSF11A",
        "hgnc": "HGNC:11908",
        "name": "TNF receptor superfamily member 11a",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11a"
      },
      {
        "slug": "tnfrsf13b",
        "symbol": "TNFRSF13B",
        "hgnc": "HGNC:18153",
        "name": "TNF receptor superfamily member 13B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf13b"
      }
    ]
  }
}