{
  "url": "https://dantelabs.com/traits/progressive-macrocephaly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "progressive-macrocephaly",
    "id": "HP:0004481",
    "name": "Progressively abnormally enlarging cranium",
    "label": "Progressive macrocephaly",
    "definition": "The progressive development of an abnormally large skull.",
    "synonyms": [
      "Progressively abnormally enlarging skull",
      "Macrocephaly, progressive"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "macrocephaly",
        "name": "Big calvaria",
        "url": "https://dantelabs.com/traits/macrocephaly"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gcdh",
        "symbol": "GCDH",
        "hgnc": "HGNC:4189",
        "name": "glutaryl-CoA dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcdh"
      },
      {
        "slug": "gfap",
        "symbol": "GFAP",
        "hgnc": "HGNC:4235",
        "name": "glial fibrillary acidic protein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gfap"
      },
      {
        "slug": "hexb",
        "symbol": "HEXB",
        "hgnc": "HGNC:4879",
        "name": "hexosaminidase subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hexb"
      },
      {
        "slug": "ndufs4",
        "symbol": "NDUFS4",
        "hgnc": "HGNC:7711",
        "name": "NADH:ubiquinone oxidoreductase subunit S4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs4"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      }
    ]
  }
}