{
  "url": "https://dantelabs.com/traits/progressive-encephalopathy",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "progressive-encephalopathy",
    "id": "HP:0002448",
    "name": "Progressive brain disease",
    "label": "Progressive encephalopathy",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "encephalopathy",
        "name": "Encephalopathy",
        "url": "https://dantelabs.com/traits/encephalopathy"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "bscl2",
        "symbol": "BSCL2",
        "hgnc": "HGNC:15832",
        "name": "BSCL2 lipid droplet biogenesis associated, seipin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bscl2"
      },
      {
        "slug": "glyctk",
        "symbol": "GLYCTK",
        "hgnc": "HGNC:24247",
        "name": "glycerate kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glyctk"
      },
      {
        "slug": "tbce",
        "symbol": "TBCE",
        "hgnc": "HGNC:11582",
        "name": "tubulin folding cofactor E",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbce"
      },
      {
        "slug": "nadk2",
        "symbol": "NADK2",
        "hgnc": "HGNC:26404",
        "name": "NAD kinase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nadk2"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "wdr45",
        "symbol": "WDR45",
        "hgnc": "HGNC:28912",
        "name": "WD repeat domain 45",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr45"
      },
      {
        "slug": "th",
        "symbol": "TH",
        "hgnc": "HGNC:11782",
        "name": "tyrosine hydroxylase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/th"
      },
      {
        "slug": "tspoap1",
        "symbol": "TSPOAP1",
        "hgnc": "HGNC:16831",
        "name": "TSPO associated protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tspoap1"
      },
      {
        "slug": "htra1",
        "symbol": "HTRA1",
        "hgnc": "HGNC:9476",
        "name": "HtrA serine peptidase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htra1"
      },
      {
        "slug": "kynu",
        "symbol": "KYNU",
        "hgnc": "HGNC:6469",
        "name": "kynureninase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kynu"
      },
      {
        "slug": "sucla2",
        "symbol": "SUCLA2",
        "hgnc": "HGNC:11448",
        "name": "succinate-CoA ligase ADP-forming subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sucla2"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      }
    ]
  }
}