{
  "url": "https://dantelabs.com/traits/mitral-annular-calcification",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "mitral-annular-calcification",
    "id": "HP:0005136",
    "name": "Mitral annular calcification",
    "definition": "Mitral annular calcification (MAC) results from progressive calcium deposition along and beneath the mitral valve annulus.",
    "synonyms": [
      "Premature calcification of mitral annulus"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "mitral-valve-calcification",
        "name": "Mitral valve calcification",
        "url": "https://dantelabs.com/traits/mitral-valve-calcification"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fbn1",
        "symbol": "FBN1",
        "hgnc": "HGNC:3603",
        "name": "fibrillin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbn1"
      }
    ]
  }
}