{
  "url": "https://dantelabs.com/traits/increased-intervertebral-space",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-intervertebral-space",
    "id": "HP:0030320",
    "name": "Increased intervertebral space",
    "definition": "An increase in the vertical distance between adjacent vertebral bodies, observed as an increase in the intervertebral disk space.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-intervertebral-disk-morphology",
        "name": "Abnormal intervertebral disk morphology",
        "url": "https://dantelabs.com/traits/abnormal-intervertebral-disk-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "extl3",
        "symbol": "EXTL3",
        "hgnc": "HGNC:3518",
        "name": "exostosin like glycosyltransferase 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/extl3"
      },
      {
        "slug": "plcb3",
        "symbol": "PLCB3",
        "hgnc": "HGNC:9056",
        "name": "phospholipase C beta 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcb3"
      },
      {
        "slug": "slc26a2",
        "symbol": "SLC26A2",
        "hgnc": "HGNC:10994",
        "name": "solute carrier family 26 member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a2"
      },
      {
        "slug": "acp5",
        "symbol": "ACP5",
        "hgnc": "HGNC:124",
        "name": "acid phosphatase 5, tartrate resistant",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acp5"
      },
      {
        "slug": "tmem53",
        "symbol": "TMEM53",
        "hgnc": "HGNC:26186",
        "name": "transmembrane protein 53",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem53"
      },
      {
        "slug": "trpv4",
        "symbol": "TRPV4",
        "hgnc": "HGNC:18083",
        "name": "transient receptor potential cation channel subfamily V member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv4"
      }
    ]
  }
}