{
  "url": "https://dantelabs.com/traits/increased-compartment-pressure",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-compartment-pressure",
    "id": "HP:6001172",
    "name": "Increased compartment pressure",
    "definition": "intracompartmental pressure (ICP) over 30 mmHg. Acute compartment syndrome occurs when there is increased pressure within a closed osteofascial compartment, resulting in impaired local circulation. Acute compartment syndrome is considered a surgical emergency since, without proper treatment, it can lead to ischemia and eventually necrosis. Generally, acute compartment syndrome is considered a clinical diagnosis. However, ICP over 30 mmHg can be used as a threshold to aid in diagnosis.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-muscle-physiology",
        "name": "Issue with muscle function",
        "url": "https://dantelabs.com/traits/abnormal-muscle-physiology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "tnxb",
        "symbol": "TNXB",
        "hgnc": "HGNC:11976",
        "name": "tenascin XB",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnxb"
      }
    ]
  }
}