{
  "url": "https://dantelabs.com/traits/hypocholesterolemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypocholesterolemia",
    "id": "HP:0003146",
    "name": "Decreased circulating cholesterol level",
    "label": "Hypocholesterolemia",
    "definition": "An decreased concentration of cholesterol in the blood.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-cholesterol-concentration",
        "name": "Abnormality of cholesterol metabolism",
        "url": "https://dantelabs.com/traits/abnormal-circulating-cholesterol-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "apob",
        "symbol": "APOB",
        "hgnc": "HGNC:603",
        "name": "apolipoprotein B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apob"
      },
      {
        "slug": "atad3a",
        "symbol": "ATAD3A",
        "hgnc": "HGNC:25567",
        "name": "ATPase family AAA domain containing 3A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atad3a"
      },
      {
        "slug": "fdft1",
        "symbol": "FDFT1",
        "hgnc": "HGNC:3629",
        "name": "farnesyl-diphosphate farnesyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdft1"
      },
      {
        "slug": "msmo1",
        "symbol": "MSMO1",
        "hgnc": "HGNC:10545",
        "name": "methylsterol monooxygenase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msmo1"
      },
      {
        "slug": "pnlip",
        "symbol": "PNLIP",
        "hgnc": "HGNC:9155",
        "name": "pancreatic lipase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnlip"
      },
      {
        "slug": "sar1b",
        "symbol": "SAR1B",
        "hgnc": "HGNC:10535",
        "name": "secretion associated Ras related GTPase 1B",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sar1b"
      },
      {
        "slug": "abca1",
        "symbol": "ABCA1",
        "hgnc": "HGNC:29",
        "name": "ATP binding cassette subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca1"
      },
      {
        "slug": "dhcr7",
        "symbol": "DHCR7",
        "hgnc": "HGNC:2860",
        "name": "7-dehydrocholesterol reductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhcr7"
      },
      {
        "slug": "mttp",
        "symbol": "MTTP",
        "hgnc": "HGNC:7467",
        "name": "microsomal triglyceride transfer protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mttp"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "tafazzin",
        "symbol": "TAFAZZIN",
        "hgnc": "HGNC:11577",
        "name": "tafazzin, phospholipid-lysophospholipid transacylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tafazzin"
      },
      {
        "slug": "ube3b",
        "symbol": "UBE3B",
        "hgnc": "HGNC:13478",
        "name": "ubiquitin protein ligase E3B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube3b"
      },
      {
        "slug": "alg12",
        "symbol": "ALG12",
        "hgnc": "HGNC:19358",
        "name": "ALG12 alpha-1,6-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg12"
      },
      {
        "slug": "serac1",
        "symbol": "SERAC1",
        "hgnc": "HGNC:21061",
        "name": "serine active site containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serac1"
      },
      {
        "slug": "flcn",
        "symbol": "FLCN",
        "hgnc": "HGNC:27310",
        "name": "folliculin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flcn"
      },
      {
        "slug": "hsd3b7",
        "symbol": "HSD3B7",
        "hgnc": "HGNC:18324",
        "name": "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd3b7"
      },
      {
        "slug": "pex12",
        "symbol": "PEX12",
        "hgnc": "HGNC:8854",
        "name": "peroxisomal biogenesis factor 12",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex12"
      },
      {
        "slug": "pmm2",
        "symbol": "PMM2",
        "hgnc": "HGNC:9115",
        "name": "phosphomannomutase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmm2"
      },
      {
        "slug": "rai1",
        "symbol": "RAI1",
        "hgnc": "HGNC:9834",
        "name": "retinoic acid induced 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rai1"
      }
    ]
  }
}