{
  "url": "https://dantelabs.com/traits/generalized-scaling",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "generalized-scaling",
    "id": "HP:0025809",
    "name": "Generalized scaling",
    "definition": "Desquamation (scaling) involving nearly all of the surface of the skin.",
    "synonyms": [
      "Diffuse desquamation",
      "Diffuse scaling"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "scaling-skin",
        "name": "Scaling skin",
        "url": "https://dantelabs.com/traits/scaling-skin"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "abca12",
        "symbol": "ABCA12",
        "hgnc": "HGNC:14637",
        "name": "ATP binding cassette subfamily A member 12",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca12"
      },
      {
        "slug": "alox12b",
        "symbol": "ALOX12B",
        "hgnc": "HGNC:430",
        "name": "arachidonate 12-lipoxygenase, 12R type",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alox12b"
      },
      {
        "slug": "aloxe3",
        "symbol": "ALOXE3",
        "hgnc": "HGNC:13743",
        "name": "arachidonate epidermal lipoxygenase 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aloxe3"
      },
      {
        "slug": "asprv1",
        "symbol": "ASPRV1",
        "hgnc": "HGNC:26321",
        "name": "aspartic peptidase retroviral like 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asprv1"
      },
      {
        "slug": "cyp4f22",
        "symbol": "CYP4F22",
        "hgnc": "HGNC:26820",
        "name": "cytochrome P450 family 4 subfamily F member 22",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp4f22"
      },
      {
        "slug": "lipn",
        "symbol": "LIPN",
        "hgnc": "HGNC:23452",
        "name": "lipase family member N",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipn"
      },
      {
        "slug": "nipal4",
        "symbol": "NIPAL4",
        "hgnc": "HGNC:28018",
        "name": "NIPA like domain containing 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nipal4"
      },
      {
        "slug": "sdr9c7",
        "symbol": "SDR9C7",
        "hgnc": "HGNC:29958",
        "name": "short chain dehydrogenase/reductase family 9C member 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdr9c7"
      },
      {
        "slug": "sult2b1",
        "symbol": "SULT2B1",
        "hgnc": "HGNC:11459",
        "name": "sulfotransferase family 2B member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sult2b1"
      },
      {
        "slug": "tgm1",
        "symbol": "TGM1",
        "hgnc": "HGNC:11777",
        "name": "transglutaminase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgm1"
      }
    ]
  }
}