{
  "url": "https://dantelabs.com/traits/focal-active-colitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "focal-active-colitis",
    "id": "HP:0033164",
    "name": "Focal active colitis",
    "definition": "Focal active colitis (FAC) is characterized by focal crypt damage caused by neutrophils. FAC is characterized by an inflammatory infiltrate consisting of intraepithelial neutrophils and/or neutrophils invading the lumen of the criptae, with no other microscopic alteration of the colonic mucosa and, in particular, without the presence of signs of chronic inflammation.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "colitis",
        "name": "Colitis",
        "url": "https://dantelabs.com/traits/colitis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dock2",
        "symbol": "DOCK2",
        "hgnc": "HGNC:2988",
        "name": "dedicator of cytokinesis 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock2"
      }
    ]
  }
}