{
  "url": "https://dantelabs.com/traits/excessive-shyness",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "excessive-shyness",
    "id": "HP:0100962",
    "name": "Shyness",
    "label": "Excessive shyness",
    "definition": "Atypically high degree of awkwardness or apprehension experienced when approaching or being approached by others.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "atypical-behavior",
        "name": "Behavioral abnormality",
        "url": "https://dantelabs.com/traits/atypical-behavior"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ap4s1",
        "symbol": "AP4S1",
        "hgnc": "HGNC:575",
        "name": "adaptor related protein complex 4 subunit sigma 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ap4s1"
      },
      {
        "slug": "taf4",
        "symbol": "TAF4",
        "hgnc": "HGNC:11537",
        "name": "TATA-box binding protein associated factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf4"
      },
      {
        "slug": "dpyd",
        "symbol": "DPYD",
        "hgnc": "HGNC:3012",
        "name": "dihydropyrimidine dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpyd"
      },
      {
        "slug": "ap4b1",
        "symbol": "AP4B1",
        "hgnc": "HGNC:572",
        "name": "adaptor related protein complex 4 subunit beta 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ap4b1"
      },
      {
        "slug": "ap4e1",
        "symbol": "AP4E1",
        "hgnc": "HGNC:573",
        "name": "adaptor related protein complex 4 subunit epsilon 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ap4e1"
      },
      {
        "slug": "nono",
        "symbol": "NONO",
        "hgnc": "HGNC:7871",
        "name": "non-POU domain containing octamer binding",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nono"
      },
      {
        "slug": "ap4m1",
        "symbol": "AP4M1",
        "hgnc": "HGNC:574",
        "name": "adaptor related protein complex 4 subunit mu 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap4m1"
      },
      {
        "slug": "ferry3",
        "symbol": "FERRY3",
        "hgnc": "HGNC:1184",
        "name": "FERRY endosomal RAB5 effector complex subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ferry3"
      },
      {
        "slug": "pola1",
        "symbol": "POLA1",
        "hgnc": "HGNC:9173",
        "name": "DNA polymerase alpha 1, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pola1"
      },
      {
        "slug": "rps6kc1",
        "symbol": "RPS6KC1",
        "hgnc": "HGNC:10439",
        "name": "ribosomal protein S6 kinase C1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps6kc1"
      },
      {
        "slug": "rlim",
        "symbol": "RLIM",
        "hgnc": "HGNC:13429",
        "name": "ring finger protein, LIM domain interacting",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rlim"
      },
      {
        "slug": "setd2",
        "symbol": "SETD2",
        "hgnc": "HGNC:18420",
        "name": "SET domain containing 2, histone lysine methyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setd2"
      }
    ]
  }
}