{
  "url": "https://dantelabs.com/traits/erythematous-macule",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "erythematous-macule",
    "id": "HP:0025475",
    "name": "Erythematous macule",
    "definition": "A macule (flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin) with a red or reddish color often associated with inflammation or irritation.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "macule",
        "name": "Flat, discolored area of skin",
        "url": "https://dantelabs.com/traits/macule"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "prkcd",
        "symbol": "PRKCD",
        "hgnc": "HGNC:9399",
        "name": "protein kinase C delta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkcd"
      },
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      }
    ]
  }
}