{
  "url": "https://dantelabs.com/traits/delayed-pubic-bone-ossification",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "delayed-pubic-bone-ossification",
    "id": "HP:0008788",
    "name": "Delayed maturation of pubic bone",
    "label": "Delayed pubic bone ossification",
    "definition": "Delayed maturation and calcification of the pubic bone.",
    "synonyms": [
      "Delayed mineralization of pubic bone",
      "Absent pubic ossification in infancy"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-ossification-of-the-pubic-bone",
        "name": "Abnormal maturation of the pubic bone",
        "url": "https://dantelabs.com/traits/abnormal-ossification-of-the-pubic-bone"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dmrt2",
        "symbol": "DMRT2",
        "hgnc": "HGNC:2935",
        "name": "doublesex and mab-3 related transcription factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmrt2"
      },
      {
        "slug": "nkx3-2",
        "symbol": "NKX3-2",
        "hgnc": "HGNC:951",
        "name": "NK3 homeobox 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx3-2"
      },
      {
        "slug": "sik3",
        "symbol": "SIK3",
        "hgnc": "HGNC:29165",
        "name": "SIK family kinase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sik3"
      },
      {
        "slug": "cbfb",
        "symbol": "CBFB",
        "hgnc": "HGNC:1539",
        "name": "core-binding factor subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbfb"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "hgnc": "HGNC:4284",
        "name": "gap junction protein beta 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb2"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "hgnc": "HGNC:4288",
        "name": "gap junction protein beta 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb6"
      },
      {
        "slug": "runx2",
        "symbol": "RUNX2",
        "hgnc": "HGNC:10472",
        "name": "RUNX family transcription factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx2"
      }
    ]
  }
}