{
  "url": "https://dantelabs.com/traits/cryptophthalmos",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cryptophthalmos",
    "id": "HP:0001126",
    "name": "Cryptophthalmos",
    "definition": "Cryptophthalmos is a condition of total absence of eyelids and the skin of forehead is continuous with that of cheek, in which the eyeball is completely concealed by the skin, which is stretched over the orbital cavity.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-eyelid",
        "name": "Failure of development of eyelid",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-eyelid"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fras1",
        "symbol": "FRAS1",
        "hgnc": "HGNC:19185",
        "name": "Fraser extracellular matrix complex subunit 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fras1"
      },
      {
        "slug": "frem2",
        "symbol": "FREM2",
        "hgnc": "HGNC:25396",
        "name": "FRAS1 related extracellular matrix 2",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/frem2"
      },
      {
        "slug": "grip1",
        "symbol": "GRIP1",
        "hgnc": "HGNC:18708",
        "name": "glutamate receptor interacting protein 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/grip1"
      },
      {
        "slug": "twist2",
        "symbol": "TWIST2",
        "hgnc": "HGNC:20670",
        "name": "twist family bHLH transcription factor 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/twist2"
      },
      {
        "slug": "frem1",
        "symbol": "FREM1",
        "hgnc": "HGNC:23399",
        "name": "FRAS1 related extracellular matrix 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/frem1"
      },
      {
        "slug": "mab21l2",
        "symbol": "MAB21L2",
        "hgnc": "HGNC:6758",
        "name": "mab-21 like 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mab21l2"
      }
    ]
  }
}