{
  "url": "https://dantelabs.com/traits/bipedal-edema",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "bipedal-edema",
    "id": "HP:0033045",
    "name": "Bipedal edema",
    "definition": "A palpable swelling in both feet and ankles caused by an increase in interstitial fluid volume (excess fluid).",
    "synonyms": [
      "Bipedal oedema"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "pedal-edema",
        "name": "Fluid accumulation in lower limbs",
        "url": "https://dantelabs.com/traits/pedal-edema"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak2"
      }
    ]
  }
}