{
  "url": "https://dantelabs.com/traits/alkalosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "alkalosis",
    "id": "HP:0001948",
    "name": "Alkalosis",
    "definition": "Depletion of acid or accumulation base in the body fluids.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-acid-base-homeostasis",
        "name": "Abnormality of acid-base homeostasis",
        "url": "https://dantelabs.com/traits/abnormality-of-acid-base-homeostasis"
      }
    ],
    "narrower": [
      {
        "slug": "metabolic-alkalosis",
        "name": "Metabolic alkalosis",
        "genes": 12,
        "url": "https://dantelabs.com/traits/metabolic-alkalosis"
      },
      {
        "slug": "respiratory-alkalosis",
        "name": "Respiratory alkalosis",
        "genes": 6,
        "url": "https://dantelabs.com/traits/respiratory-alkalosis"
      },
      {
        "slug": "hypokalemic-alkalosis",
        "name": "Hypokalemic alkalosis",
        "genes": 3,
        "url": "https://dantelabs.com/traits/hypokalemic-alkalosis"
      },
      {
        "slug": "hypochloremic-metabolic-alkalosis",
        "name": "Hypochloremic metabolic alkalosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hypochloremic-metabolic-alkalosis"
      }
    ],
    "genes": [
      {
        "slug": "nags",
        "symbol": "NAGS",
        "hgnc": "HGNC:17996",
        "name": "N-acetylglutamate synthase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nags"
      },
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "slc26a3",
        "symbol": "SLC26A3",
        "hgnc": "HGNC:3018",
        "name": "solute carrier family 26 member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a3"
      },
      {
        "slug": "usp8",
        "symbol": "USP8",
        "hgnc": "HGNC:12631",
        "name": "ubiquitin specific peptidase 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp8"
      }
    ]
  }
}