{
  "url": "https://dantelabs.com/traits/age-inappropriate-oppositional-behavior",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "age-inappropriate-oppositional-behavior",
    "id": "HP:0010865",
    "name": "Age-inappropriate oppositional behavior",
    "definition": "A pervasive and characteristic pattern of arguing, defiance, and hostility toward others, particularly authority figures, that goes beyond the occasional oppositionality seen as a normal behavior in individuals at a certain age, e.g., during child and adolescent development.",
    "synonyms": [
      "Developmentally inappropriate oppositional behavior",
      "Excessive oppositional behavior"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "aggressive-behavior",
        "name": "Aggressive behavior",
        "url": "https://dantelabs.com/traits/aggressive-behavior"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "lsm7",
        "symbol": "LSM7",
        "hgnc": "HGNC:20470",
        "name": "LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lsm7"
      },
      {
        "slug": "mark2",
        "symbol": "MARK2",
        "hgnc": "HGNC:3332",
        "name": "microtubule affinity regulating kinase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mark2"
      },
      {
        "slug": "msl2",
        "symbol": "MSL2",
        "hgnc": "HGNC:25544",
        "name": "MSL complex subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msl2"
      },
      {
        "slug": "coq5",
        "symbol": "COQ5",
        "hgnc": "HGNC:28722",
        "name": "coenzyme Q5, methyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq5"
      },
      {
        "slug": "gns",
        "symbol": "GNS",
        "hgnc": "HGNC:4422",
        "name": "glucosamine (N-acetyl)-6-sulfatase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gns"
      },
      {
        "slug": "hivep2",
        "symbol": "HIVEP2",
        "hgnc": "HGNC:4921",
        "name": "HIVEP zinc finger 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hivep2"
      }
    ]
  }
}