{
  "url": "https://dantelabs.com/traits/action-tremor",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "action-tremor",
    "id": "HP:0002345",
    "name": "Action tremor",
    "definition": "A tremor present when the limbs are active, either when outstretched in a certain position or throughout a voluntary movement.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "tremor",
        "name": "Tremor",
        "url": "https://dantelabs.com/traits/tremor"
      }
    ],
    "narrower": [
      {
        "slug": "postural-tremor",
        "name": "Postural tremor",
        "genes": 67,
        "url": "https://dantelabs.com/traits/postural-tremor"
      },
      {
        "slug": "kinetic-tremor",
        "name": "Kinetic tremor",
        "genes": 9,
        "url": "https://dantelabs.com/traits/kinetic-tremor"
      },
      {
        "slug": "titubation",
        "name": "Titubation",
        "genes": 8,
        "url": "https://dantelabs.com/traits/titubation"
      },
      {
        "slug": "isometric-tremor",
        "name": "Isometric tremor",
        "genes": 2,
        "url": "https://dantelabs.com/traits/isometric-tremor"
      },
      {
        "slug": "vocal-tremor",
        "name": "Vocal tremor",
        "genes": 2,
        "url": "https://dantelabs.com/traits/vocal-tremor"
      }
    ],
    "genes": [
      {
        "slug": "atp2b3",
        "symbol": "ATP2B3",
        "hgnc": "HGNC:816",
        "name": "ATPase plasma membrane Ca2+ transporting 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp2b3"
      },
      {
        "slug": "itpr1",
        "symbol": "ITPR1",
        "hgnc": "HGNC:6180",
        "name": "inositol 1,4,5-trisphosphate receptor type 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/itpr1"
      },
      {
        "slug": "unc13a",
        "symbol": "UNC13A",
        "hgnc": "HGNC:23150",
        "name": "unc-13 homolog A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13a"
      },
      {
        "slug": "uroc1",
        "symbol": "UROC1",
        "hgnc": "HGNC:26444",
        "name": "urocanate hydratase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/uroc1"
      },
      {
        "slug": "wars2",
        "symbol": "WARS2",
        "hgnc": "HGNC:12730",
        "name": "tryptophanyl tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wars2"
      },
      {
        "slug": "atn1",
        "symbol": "ATN1",
        "hgnc": "HGNC:3033",
        "name": "atrophin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atn1"
      },
      {
        "slug": "atp6ap2",
        "symbol": "ATP6AP2",
        "hgnc": "HGNC:18305",
        "name": "ATPase H+ transporting accessory protein 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp6ap2"
      },
      {
        "slug": "clcn2",
        "symbol": "CLCN2",
        "hgnc": "HGNC:2020",
        "name": "chloride voltage-gated channel 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn2"
      },
      {
        "slug": "col6a3",
        "symbol": "COL6A3",
        "hgnc": "HGNC:2213",
        "name": "collagen type VI alpha 3 chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col6a3"
      },
      {
        "slug": "galt",
        "symbol": "GALT",
        "hgnc": "HGNC:4135",
        "name": "galactose-1-phosphate uridylyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galt"
      },
      {
        "slug": "ggt1",
        "symbol": "GGT1",
        "hgnc": "HGNC:4250",
        "name": "gamma-glutamyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ggt1"
      },
      {
        "slug": "kcnj10",
        "symbol": "KCNJ10",
        "hgnc": "HGNC:6256",
        "name": "potassium inwardly rectifying channel subfamily J member 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj10"
      },
      {
        "slug": "ppp2r2b",
        "symbol": "PPP2R2B",
        "hgnc": "HGNC:9305",
        "name": "protein phosphatase 2 regulatory subunit Bbeta",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ppp2r2b"
      },
      {
        "slug": "rtn2",
        "symbol": "RTN2",
        "hgnc": "HGNC:10468",
        "name": "reticulon 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtn2"
      },
      {
        "slug": "slc19a3",
        "symbol": "SLC19A3",
        "hgnc": "HGNC:16266",
        "name": "solute carrier family 19 member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc19a3"
      },
      {
        "slug": "slc30a10",
        "symbol": "SLC30A10",
        "hgnc": "HGNC:25355",
        "name": "solute carrier family 30 member 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc30a10"
      },
      {
        "slug": "gabra1",
        "symbol": "GABRA1",
        "hgnc": "HGNC:4075",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra1"
      },
      {
        "slug": "gabrg2",
        "symbol": "GABRG2",
        "hgnc": "HGNC:4087",
        "name": "gamma-aminobutyric acid type A receptor subunit gamma2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabrg2"
      },
      {
        "slug": "lmnb1",
        "symbol": "LMNB1",
        "hgnc": "HGNC:6637",
        "name": "lamin B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmnb1"
      },
      {
        "slug": "ngly1",
        "symbol": "NGLY1",
        "hgnc": "HGNC:17646",
        "name": "N-glycanase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ngly1"
      },
      {
        "slug": "nol3",
        "symbol": "NOL3",
        "hgnc": "HGNC:7869",
        "name": "nucleolar protein 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nol3"
      },
      {
        "slug": "nptx1",
        "symbol": "NPTX1",
        "hgnc": "HGNC:7952",
        "name": "neuronal pentraxin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nptx1"
      },
      {
        "slug": "pcdh19",
        "symbol": "PCDH19",
        "hgnc": "HGNC:14270",
        "name": "protocadherin 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcdh19"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "polr3a",
        "symbol": "POLR3A",
        "hgnc": "HGNC:30074",
        "name": "RNA polymerase III subunit A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3a"
      },
      {
        "slug": "rrm1",
        "symbol": "RRM1",
        "hgnc": "HGNC:10451",
        "name": "ribonucleotide reductase catalytic subunit M1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm1"
      },
      {
        "slug": "scn1a",
        "symbol": "SCN1A",
        "hgnc": "HGNC:10585",
        "name": "sodium voltage-gated channel alpha subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1a"
      },
      {
        "slug": "scn1b",
        "symbol": "SCN1B",
        "hgnc": "HGNC:10586",
        "name": "sodium voltage-gated channel beta subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1b"
      },
      {
        "slug": "scn2a",
        "symbol": "SCN2A",
        "hgnc": "HGNC:10588",
        "name": "sodium voltage-gated channel alpha subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn2a"
      },
      {
        "slug": "scn9a",
        "symbol": "SCN9A",
        "hgnc": "HGNC:10597",
        "name": "sodium voltage-gated channel alpha subunit 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn9a"
      },
      {
        "slug": "tk2",
        "symbol": "TK2",
        "hgnc": "HGNC:11831",
        "name": "thymidine kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tk2"
      },
      {
        "slug": "top3a",
        "symbol": "TOP3A",
        "hgnc": "HGNC:11992",
        "name": "DNA topoisomerase III alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/top3a"
      },
      {
        "slug": "ywhag",
        "symbol": "YWHAG",
        "hgnc": "HGNC:12852",
        "name": "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ywhag"
      },
      {
        "slug": "dnajc19",
        "symbol": "DNAJC19",
        "hgnc": "HGNC:30528",
        "name": "DnaJ heat shock protein family (Hsp40) member C19",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc19"
      },
      {
        "slug": "atxn2",
        "symbol": "ATXN2",
        "hgnc": "HGNC:10555",
        "name": "ataxin 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn2"
      },
      {
        "slug": "drd3",
        "symbol": "DRD3",
        "hgnc": "HGNC:3024",
        "name": "dopamine receptor D3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drd3"
      },
      {
        "slug": "fmr1",
        "symbol": "FMR1",
        "hgnc": "HGNC:3775",
        "name": "fragile X messenger ribonucleoprotein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fmr1"
      },
      {
        "slug": "fus",
        "symbol": "FUS",
        "hgnc": "HGNC:4010",
        "name": "FUS RNA binding protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fus"
      },
      {
        "slug": "jph3",
        "symbol": "JPH3",
        "hgnc": "HGNC:14203",
        "name": "junctophilin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jph3"
      },
      {
        "slug": "mpz",
        "symbol": "MPZ",
        "hgnc": "HGNC:7225",
        "name": "myelin protein zero",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpz"
      },
      {
        "slug": "pmp22",
        "symbol": "PMP22",
        "hgnc": "HGNC:9118",
        "name": "peripheral myelin protein 22",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmp22"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "slc9a1",
        "symbol": "SLC9A1",
        "hgnc": "HGNC:11071",
        "name": "solute carrier family 9 member A1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc9a1"
      }
    ]
  }
}