{
  "url": "https://dantelabs.com/traits/abnormal-circulating-interleukin-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-interleukin-concentration",
    "id": "HP:0011117",
    "name": "Abnormal circulating interleukin concentration",
    "definition": "The concentration of an interleukin (a class of cytokines) is outside the limits of normal.",
    "synonyms": [
      "Abnormal serum IL level",
      "Abnormal serum interleukin level",
      "Abnormality of IL secretion",
      "Abnormality of interleukin secretion"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-cytokine-concentration",
        "name": "Abnormal circulating cytokine concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-cytokine-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "increased-circulating-interleukin-18-concentration",
        "name": "Increased circulating interleukin 18 concentration",
        "genes": 5,
        "url": "https://dantelabs.com/traits/increased-circulating-interleukin-18-concentration"
      },
      {
        "slug": "increased-circulating-interleukin-1beta-concentration",
        "name": "Increased circulating interleukin 1beta concentration",
        "genes": 3,
        "url": "https://dantelabs.com/traits/increased-circulating-interleukin-1beta-concentration"
      },
      {
        "slug": "increased-circulating-interleukin-8-concentration",
        "name": "Increased circulating interleukin 8 concentration",
        "genes": 3,
        "url": "https://dantelabs.com/traits/increased-circulating-interleukin-8-concentration"
      },
      {
        "slug": "abnormal-circulating-interleukin-10-concentration",
        "name": "Abnormal circulating interleukin 10 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-interleukin-10-concentration"
      },
      {
        "slug": "abnormal-circulating-interleukin-17a-concentration",
        "name": "Abnormal circulating interleukin 17A concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-interleukin-17a-concentration"
      },
      {
        "slug": "abnormal-circulating-interleukin-21-concentration",
        "name": "Abnormal circulating interleukin 21 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-interleukin-21-concentration"
      },
      {
        "slug": "abnormal-circulating-interleukin-22-concentration",
        "name": "Abnormal circulating interleukin 22 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-interleukin-22-concentration"
      },
      {
        "slug": "abnormal-circulating-interleukin-23-concentration",
        "name": "Abnormal circulating interleukin 23 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-interleukin-23-concentration"
      },
      {
        "slug": "abnormal-circulating-interleukin-27-concentration",
        "name": "Abnormal circulating interleukin 27 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-interleukin-27-concentration"
      },
      {
        "slug": "abnormal-circulating-interleukin-6-concentration",
        "name": "Abnormal circulating interleukin 6 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-interleukin-6-concentration"
      }
    ],
    "genes": [
      {
        "slug": "il12rb1",
        "symbol": "IL12RB1",
        "hgnc": "HGNC:5971",
        "name": "interleukin 12 receptor subunit beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12rb1"
      },
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "ptpn6",
        "symbol": "PTPN6",
        "hgnc": "HGNC:9658",
        "name": "protein tyrosine phosphatase non-receptor type 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn6"
      },
      {
        "slug": "sp110",
        "symbol": "SP110",
        "hgnc": "HGNC:5401",
        "name": "SP110 nuclear body protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sp110"
      },
      {
        "slug": "ankrd55",
        "symbol": "ANKRD55",
        "hgnc": "HGNC:25681",
        "name": "ankyrin repeat domain 55",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankrd55"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "cd247",
        "symbol": "CD247",
        "hgnc": "HGNC:1677",
        "name": "CD247 molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd247"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "il2ra",
        "symbol": "IL2RA",
        "hgnc": "HGNC:6008",
        "name": "interleukin 2 receptor subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2ra"
      },
      {
        "slug": "il2rb",
        "symbol": "IL2RB",
        "hgnc": "HGNC:6009",
        "name": "interleukin 2 receptor subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2rb"
      },
      {
        "slug": "ptpn2",
        "symbol": "PTPN2",
        "hgnc": "HGNC:9650",
        "name": "protein tyrosine phosphatase non-receptor type 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn2"
      },
      {
        "slug": "ptpn22",
        "symbol": "PTPN22",
        "hgnc": "HGNC:9652",
        "name": "protein tyrosine phosphatase non-receptor type 22",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn22"
      },
      {
        "slug": "stat4",
        "symbol": "STAT4",
        "hgnc": "HGNC:11365",
        "name": "signal transducer and activator of transcription 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat4"
      },
      {
        "slug": "abcb11",
        "symbol": "ABCB11",
        "hgnc": "HGNC:42",
        "name": "ATP binding cassette subfamily B member 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb11"
      },
      {
        "slug": "abcb4",
        "symbol": "ABCB4",
        "hgnc": "HGNC:45",
        "name": "ATP binding cassette subfamily B member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb4"
      },
      {
        "slug": "atp8b1",
        "symbol": "ATP8B1",
        "hgnc": "HGNC:3706",
        "name": "ATPase phospholipid transporting 8B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp8b1"
      },
      {
        "slug": "nr1h4",
        "symbol": "NR1H4",
        "hgnc": "HGNC:7967",
        "name": "nuclear receptor subfamily 1 group H member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr1h4"
      }
    ]
  }
}