{
  "url": "https://dantelabs.com/traits/abnormal-circulating-igm-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-igm-concentration",
    "id": "HP:0410243",
    "name": "Abnormal circulating IgM concentration",
    "definition": "An abnormal deviation from normal levels of IgM immunoglobulin in blood.",
    "synonyms": [
      "Abnormal circulating IgM level",
      "Abnormal IgM level in blood"
    ],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-immunoglobulin-concentration",
        "name": "Abnormal circulating immunoglobulin concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-immunoglobulin-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-circulating-igm-concentration",
        "name": "Decreased circulating IgM concentration",
        "genes": 85,
        "url": "https://dantelabs.com/traits/decreased-circulating-igm-concentration"
      },
      {
        "slug": "increased-circulating-igm-concentration",
        "name": "Increased circulating IgM concentration",
        "genes": 35,
        "url": "https://dantelabs.com/traits/increased-circulating-igm-concentration"
      }
    ],
    "genes": [
      {
        "slug": "pomp",
        "symbol": "POMP",
        "hgnc": "HGNC:20330",
        "name": "proteasome maturation protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomp"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "alg12",
        "symbol": "ALG12",
        "hgnc": "HGNC:19358",
        "name": "ALG12 alpha-1,6-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg12"
      }
    ]
  }
}